Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region
Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis is an uncommon complication of this infection. The aim of this study was to present unusual clinical manifestations and to discuss the management and outcome of a series of 18 neurobrucellosis cases. Initial clinic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2011-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867011701404 |
| _version_ | 1818520330263592960 |
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| author | Nurgul Ceran Recai Turkoglu Ilknur Erdem Asuman Inan Derya Engin Hulya Tireli Pasa Goktas |
| author_facet | Nurgul Ceran Recai Turkoglu Ilknur Erdem Asuman Inan Derya Engin Hulya Tireli Pasa Goktas |
| author_sort | Nurgul Ceran |
| collection | DOAJ |
| description | Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis is an uncommon complication of this infection. The aim of this study was to present unusual clinical manifestations and to discuss the management and outcome of a series of 18 neurobrucellosis cases. Initial clinical manifestations consist of pseudotumor cerebri in one case, white matter lesions and demyelinating syndrome in three cases, intracranial granuloma in one case, transverse myelitis in two cases, sagittal sinus thrombosis in one case, spinal arachnoiditis in one case, intracranial vasculitis in one case, in addition to meningitis in all cases. Eleven patients were male and seven were female. The most prevalent symptoms were headache (83%) and fever (44%). All patients were treated with rifampicin, doxycycline plus trimethoprim-sulfamethoxazole or ceftriaxone. Duration of treatment (varied 3-12 months) was determined on basis of the CSF response. In four patients presented with left mild sequelae including aphasia, hearing loss, hemiparesis. In conclusion, although mortality is rare in neurobrucellosis, its sequelae are significant. In neurobrucellosis various clinical and neuroradiologic signs and symptoms can be confused with other neurologic diseases. In inhabitants or visitors of endemic areas, neurobrucellosis should be kept in mind in cases that have unusual neurological manifestations. Keywords: neurobrucellosis, serology, diagnosis, neuroimaging |
| first_indexed | 2024-12-11T01:35:57Z |
| format | Article |
| id | doaj.art-339469609b4e4bd58d12931ac8ec39d3 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-11T01:35:57Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-339469609b4e4bd58d12931ac8ec39d32022-12-22T01:25:13ZengElsevierBrazilian Journal of Infectious Diseases1413-86702011-01-011515259Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic regionNurgul Ceran0Recai Turkoglu1Ilknur Erdem2Asuman Inan3Derya Engin4Hulya Tireli5Pasa Goktas6Department of Infectious Diseases Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey; Correspondence to: Harem Iskele Caddesi, 80/12 Uskudar, 34668 Istanbul, Turkey Phone: +90 216 3917120.Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyNeurology, Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases Haydarpasa Numune Training and Research Hospital, Istanbul, TurkeyBrucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis is an uncommon complication of this infection. The aim of this study was to present unusual clinical manifestations and to discuss the management and outcome of a series of 18 neurobrucellosis cases. Initial clinical manifestations consist of pseudotumor cerebri in one case, white matter lesions and demyelinating syndrome in three cases, intracranial granuloma in one case, transverse myelitis in two cases, sagittal sinus thrombosis in one case, spinal arachnoiditis in one case, intracranial vasculitis in one case, in addition to meningitis in all cases. Eleven patients were male and seven were female. The most prevalent symptoms were headache (83%) and fever (44%). All patients were treated with rifampicin, doxycycline plus trimethoprim-sulfamethoxazole or ceftriaxone. Duration of treatment (varied 3-12 months) was determined on basis of the CSF response. In four patients presented with left mild sequelae including aphasia, hearing loss, hemiparesis. In conclusion, although mortality is rare in neurobrucellosis, its sequelae are significant. In neurobrucellosis various clinical and neuroradiologic signs and symptoms can be confused with other neurologic diseases. In inhabitants or visitors of endemic areas, neurobrucellosis should be kept in mind in cases that have unusual neurological manifestations. Keywords: neurobrucellosis, serology, diagnosis, neuroimaginghttp://www.sciencedirect.com/science/article/pii/S1413867011701404 |
| spellingShingle | Nurgul Ceran Recai Turkoglu Ilknur Erdem Asuman Inan Derya Engin Hulya Tireli Pasa Goktas Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region Brazilian Journal of Infectious Diseases |
| title | Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region |
| title_full | Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region |
| title_fullStr | Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region |
| title_full_unstemmed | Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region |
| title_short | Neurobrucellosis: clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region |
| title_sort | neurobrucellosis clinical diagnostic therapeutic features and outcome unusual clinical presentations in an endemic region |
| url | http://www.sciencedirect.com/science/article/pii/S1413867011701404 |
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