Sex modifies the renal consequences of high fructose consumption introduced after weaning
After lactation, many children consume fructose-rich processed foods. However, overconsumption of these foods can predispose individuals to non-communicable chronic diseases, which can have different repercussions depending on the sex. Thus, we evaluated the effects of fructose overload introduced a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1090090/full |
| _version_ | 1797870434335588352 |
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| author | Letícia Maria Monteiro Letícia Maria Monteiro Celine Farias Barbosa Débora Conte Kimura Lichtenecker Rogério Argeri Rogério Argeri Guiomar Nascimento Gomes |
| author_facet | Letícia Maria Monteiro Letícia Maria Monteiro Celine Farias Barbosa Débora Conte Kimura Lichtenecker Rogério Argeri Rogério Argeri Guiomar Nascimento Gomes |
| author_sort | Letícia Maria Monteiro |
| collection | DOAJ |
| description | After lactation, many children consume fructose-rich processed foods. However, overconsumption of these foods can predispose individuals to non-communicable chronic diseases, which can have different repercussions depending on the sex. Thus, we evaluated the effects of fructose overload introduced after weaning on the renal function of young rats of both sexes.Methods: After weaning, male and female offspring of Wistar rats were assigned to drink water (the male/water and female/water groups) or 20% D-fructose solution (male/fructose and female/fructose groups). Food and water or fructose solution was offered ad libitum. Rats were evaluated at 4 months. Parameters analyzed: blood pressure, body weight, triglyceride levels, glomerular filtration rate, sodium, potassium, calcium, and magnesium excretion, macrophage infiltration, and eNOS and 8OHdG expression in renal tissue. CEUA-UNIFESP: 2757270117.Results: Fructose intake affected the blood pressure, body weight, and plasma triglyceride in all rats. Glomerular filtration rate was significantly reduced in males that received fructose when compared to that of the control group. Sodium and potassium excretion decreased in all fructose-treated rats; however, the excreted load of these ions was significantly higher in females than in males. In the female control group, calcium excretion was higher than that of the male control group. Fructose overload increased magnesium excretion in females, and also increased macrophage infiltration and reduced eNOS expression in both males and females.Conclusion: Fructose overload introduced after weaning caused metabolic and renal changes in rats. Renal function was more affected in males; however, several significant alterations were also observed in the female-fructose group. |
| first_indexed | 2024-04-10T00:27:27Z |
| format | Article |
| id | doaj.art-33953f75d8f04bc49e7ead3eed17ea6a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T00:27:27Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-33953f75d8f04bc49e7ead3eed17ea6a2023-03-15T05:38:09ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-03-011410.3389/fphys.2023.10900901090090Sex modifies the renal consequences of high fructose consumption introduced after weaningLetícia Maria Monteiro0Letícia Maria Monteiro1Celine Farias Barbosa2Débora Conte Kimura Lichtenecker3Rogério Argeri4Rogério Argeri5Guiomar Nascimento Gomes6Department of Physiology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilPostgraduate Program in Translational Medicine, Department of Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilPostgraduate Program in Translational Medicine, Department of Medicine, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilDepartment of Physiology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, BrazilAfter lactation, many children consume fructose-rich processed foods. However, overconsumption of these foods can predispose individuals to non-communicable chronic diseases, which can have different repercussions depending on the sex. Thus, we evaluated the effects of fructose overload introduced after weaning on the renal function of young rats of both sexes.Methods: After weaning, male and female offspring of Wistar rats were assigned to drink water (the male/water and female/water groups) or 20% D-fructose solution (male/fructose and female/fructose groups). Food and water or fructose solution was offered ad libitum. Rats were evaluated at 4 months. Parameters analyzed: blood pressure, body weight, triglyceride levels, glomerular filtration rate, sodium, potassium, calcium, and magnesium excretion, macrophage infiltration, and eNOS and 8OHdG expression in renal tissue. CEUA-UNIFESP: 2757270117.Results: Fructose intake affected the blood pressure, body weight, and plasma triglyceride in all rats. Glomerular filtration rate was significantly reduced in males that received fructose when compared to that of the control group. Sodium and potassium excretion decreased in all fructose-treated rats; however, the excreted load of these ions was significantly higher in females than in males. In the female control group, calcium excretion was higher than that of the male control group. Fructose overload increased magnesium excretion in females, and also increased macrophage infiltration and reduced eNOS expression in both males and females.Conclusion: Fructose overload introduced after weaning caused metabolic and renal changes in rats. Renal function was more affected in males; however, several significant alterations were also observed in the female-fructose group.https://www.frontiersin.org/articles/10.3389/fphys.2023.1090090/fullrenal functionfructose overloadsexual dimorphismelectrolyte excretionblood pressure |
| spellingShingle | Letícia Maria Monteiro Letícia Maria Monteiro Celine Farias Barbosa Débora Conte Kimura Lichtenecker Rogério Argeri Rogério Argeri Guiomar Nascimento Gomes Sex modifies the renal consequences of high fructose consumption introduced after weaning Frontiers in Physiology renal function fructose overload sexual dimorphism electrolyte excretion blood pressure |
| title | Sex modifies the renal consequences of high fructose consumption introduced after weaning |
| title_full | Sex modifies the renal consequences of high fructose consumption introduced after weaning |
| title_fullStr | Sex modifies the renal consequences of high fructose consumption introduced after weaning |
| title_full_unstemmed | Sex modifies the renal consequences of high fructose consumption introduced after weaning |
| title_short | Sex modifies the renal consequences of high fructose consumption introduced after weaning |
| title_sort | sex modifies the renal consequences of high fructose consumption introduced after weaning |
| topic | renal function fructose overload sexual dimorphism electrolyte excretion blood pressure |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1090090/full |
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