Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability
Background/Aims: The serum anti-Helicobacter pylori (H. pylori) immunoglobulin G (IgG) and serum pepsinogen (PG) assays are widely used to screen for gastric cancer. An equivocal serology test finding indicates IgG titer between the positive and negative test findings. This study aims to evaluate th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Jin Publishing & Printing Co.
2017-10-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2017.70.4.181 |
| _version_ | 1818033045027946496 |
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| author | Ji Hye Kim Sun-Young Lee Hyun Gyung Kwon Sang Pyo Lee Jeong Hwan Kim In-Kyung Sung Hyung Seok Park Chan Sup Shim |
| author_facet | Ji Hye Kim Sun-Young Lee Hyun Gyung Kwon Sang Pyo Lee Jeong Hwan Kim In-Kyung Sung Hyung Seok Park Chan Sup Shim |
| author_sort | Ji Hye Kim |
| collection | DOAJ |
| description | Background/Aims: The serum anti-Helicobacter pylori (H. pylori) immunoglobulin G (IgG) and serum pepsinogen (PG) assays are widely used to screen for gastric cancer. An equivocal serology test finding indicates IgG titer between the positive and negative test findings. This study aims to evaluate the long-term follow-up result after an equivocal test finding on the serum anti-H. pylori IgG assay.
Methods: Koreans aged 18 years or older with an equivocal serum anti-H. pylori IgG assay finding were included. Subjects were excluded if they did not undergo H. pylori serology test, serum PG assay, and upper gastrointestinal (UGI) endoscopy on the same day at our center. The annual test findings were followed-up using the same methods.
Results: Of the 7,178 subjects who underwent the serum assays and UGI endoscopy on the same day, 274 (3.8%) subjects showed an equivocal H. pylori serology test finding. Of the 98 subjects who were followed-up, 58 (59.2%) showed seropositive finding at the mean follow-up period of 30.6±12.4 months. Subjects with seroconversion showed a higher initial serum PG I (p=0.023) and PG II (p=0.036) levels than those without seroconversion.
Conclusions: An equivocal H. pylori serology test finding was not rare (3.8%) in Korean adults, and 60% of equivocal subjects showed seroconversion within 3 years. Higher seroconversion rates in subjects with high PG I and PG II levels suggest that intact gastric secreting ability plays a role in the survival of H. pylori. Therefore, equivocal subjects with increased serum PG levels should be considered as potential seropositive subjects. |
| first_indexed | 2024-12-10T06:17:01Z |
| format | Article |
| id | doaj.art-339673fcba384c5f8d531947bc257768 |
| institution | Directory Open Access Journal |
| issn | 1598-9992 |
| language | English |
| last_indexed | 2024-12-10T06:17:01Z |
| publishDate | 2017-10-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-339673fcba384c5f8d531947bc2577682022-12-22T01:59:26ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922017-10-0170418118910.4166/kjg.2017.70.4.181kjg.2017.70.4.181Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting AbilityJi Hye Kim0Sun-Young Lee1Hyun Gyung Kwon2Sang Pyo Lee3Jeong Hwan Kim4In-Kyung Sung5Hyung Seok Park6Chan Sup Shim7Department of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaBackground/Aims: The serum anti-Helicobacter pylori (H. pylori) immunoglobulin G (IgG) and serum pepsinogen (PG) assays are widely used to screen for gastric cancer. An equivocal serology test finding indicates IgG titer between the positive and negative test findings. This study aims to evaluate the long-term follow-up result after an equivocal test finding on the serum anti-H. pylori IgG assay. Methods: Koreans aged 18 years or older with an equivocal serum anti-H. pylori IgG assay finding were included. Subjects were excluded if they did not undergo H. pylori serology test, serum PG assay, and upper gastrointestinal (UGI) endoscopy on the same day at our center. The annual test findings were followed-up using the same methods. Results: Of the 7,178 subjects who underwent the serum assays and UGI endoscopy on the same day, 274 (3.8%) subjects showed an equivocal H. pylori serology test finding. Of the 98 subjects who were followed-up, 58 (59.2%) showed seropositive finding at the mean follow-up period of 30.6±12.4 months. Subjects with seroconversion showed a higher initial serum PG I (p=0.023) and PG II (p=0.036) levels than those without seroconversion. Conclusions: An equivocal H. pylori serology test finding was not rare (3.8%) in Korean adults, and 60% of equivocal subjects showed seroconversion within 3 years. Higher seroconversion rates in subjects with high PG I and PG II levels suggest that intact gastric secreting ability plays a role in the survival of H. pylori. Therefore, equivocal subjects with increased serum PG levels should be considered as potential seropositive subjects.http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2017.70.4.181Helicobacter pyloriPepsinogenSerology |
| spellingShingle | Ji Hye Kim Sun-Young Lee Hyun Gyung Kwon Sang Pyo Lee Jeong Hwan Kim In-Kyung Sung Hyung Seok Park Chan Sup Shim Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability The Korean Journal of Gastroenterology Helicobacter pylori Pepsinogen Serology |
| title | Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability |
| title_full | Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability |
| title_fullStr | Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability |
| title_full_unstemmed | Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability |
| title_short | Serological Changes after Equivocal Helicobacter pylori-serology Test Findings Dependent on Gastric Secreting Ability |
| title_sort | serological changes after equivocal helicobacter pylori serology test findings dependent on gastric secreting ability |
| topic | Helicobacter pylori Pepsinogen Serology |
| url | http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2017.70.4.181 |
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