Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.

Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.

High-grade gliomas (World Health Organization grade III anaplastic astrocytoma and grade IV glioblastoma multiforme), the most prevalent primary malignant brain tumors, display a cellular hierarchy with self-renewing, tumorigenic cancer stem cells (CSCs) at the apex. While the CSC hypothesis has bee...

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Bibliographic Details
Main Authors: Justin D Lathia, Joseph Gallagher, Jay T Myers, Meizhang Li, Amit Vasanji, Roger E McLendon, Anita B Hjelmeland, Alex Y Huang, Jeremy N Rich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3178553?pdf=render

Internet

http://europepmc.org/articles/PMC3178553?pdf=render

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