Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management
Abstract Hard‐healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend to achieve multistage promotion and real‐time reporting to facilitate wound management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for wound h...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202206900 |
| _version_ | 1797825236935114752 |
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| author | Li Wang Guopu Chen Lu Fan Hanxu Chen Yuanjin Zhao Ling Lu Luoran Shang |
| author_facet | Li Wang Guopu Chen Lu Fan Hanxu Chen Yuanjin Zhao Ling Lu Luoran Shang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Abstract Hard‐healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend to achieve multistage promotion and real‐time reporting to facilitate wound management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for wound healing, which is intergated with glucose oxidase (GOD) and copper peroxide (CP). Such microparticles are composed of biofriendly hyaluronic acid methacryloyl (HAMA) and pH‐responsive acrylic acid (AA), which provided abundant binding sites and spaces for chemical immobilizing and physical doping of enzymes and metal bioinorganics. When the cascade catalytic system is applied on wound sites, hyperglycemia environment would serve as a hydrogen peroxide (H2O2) generator through GOD catalysis, while acidic environment triggers the decomposition of CP, further catalyzing H2O2 to generate reactive oxygen species (ROS). Additionally, the distinctive structural color of the microparticles can visually reflect the wound pH and intelligently estimate the healing state. It is demonstrated that such microparticle systems exhibit excellent broad‐spectrum antibacterial and angiogenesis‐promoting properties, as well as significant real‐time reporting ability for wound healing. These features indicate that enzyme cascade structural color microparticles possess valuable potential in wound healing and related field. |
| first_indexed | 2024-03-13T10:51:03Z |
| format | Article |
| id | doaj.art-3398a4ac4bdc422fbc6843df01887f7a |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-13T10:51:03Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-3398a4ac4bdc422fbc6843df01887f7a2023-05-17T13:02:05ZengWileyAdvanced Science2198-38442023-05-011014n/an/a10.1002/advs.202206900Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing ManagementLi Wang0Guopu Chen1Lu Fan2Hanxu Chen3Yuanjin Zhao4Ling Lu5Luoran Shang6Department of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaDepartment of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaDepartment of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaDepartment of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaDepartment of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaDepartment of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaDepartment of Otolaryngology Head and Neck Surgery Institute of Translational Medicine Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. ChinaAbstract Hard‐healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend to achieve multistage promotion and real‐time reporting to facilitate wound management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for wound healing, which is intergated with glucose oxidase (GOD) and copper peroxide (CP). Such microparticles are composed of biofriendly hyaluronic acid methacryloyl (HAMA) and pH‐responsive acrylic acid (AA), which provided abundant binding sites and spaces for chemical immobilizing and physical doping of enzymes and metal bioinorganics. When the cascade catalytic system is applied on wound sites, hyperglycemia environment would serve as a hydrogen peroxide (H2O2) generator through GOD catalysis, while acidic environment triggers the decomposition of CP, further catalyzing H2O2 to generate reactive oxygen species (ROS). Additionally, the distinctive structural color of the microparticles can visually reflect the wound pH and intelligently estimate the healing state. It is demonstrated that such microparticle systems exhibit excellent broad‐spectrum antibacterial and angiogenesis‐promoting properties, as well as significant real‐time reporting ability for wound healing. These features indicate that enzyme cascade structural color microparticles possess valuable potential in wound healing and related field.https://doi.org/10.1002/advs.202206900antibacterialhydrogelinverse opalreactive oxygen species (ROS)wound healing |
| spellingShingle | Li Wang Guopu Chen Lu Fan Hanxu Chen Yuanjin Zhao Ling Lu Luoran Shang Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management Advanced Science antibacterial hydrogel inverse opal reactive oxygen species (ROS) wound healing |
| title | Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management |
| title_full | Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management |
| title_fullStr | Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management |
| title_full_unstemmed | Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management |
| title_short | Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management |
| title_sort | biomimetic enzyme cascade structural color hydrogel microparticles for diabetic wound healing management |
| topic | antibacterial hydrogel inverse opal reactive oxygen species (ROS) wound healing |
| url | https://doi.org/10.1002/advs.202206900 |
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