MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts

MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts

Fluoride overexposure is an environmental health hazard and can cause enamel and skeletal fluorosis. Previously we demonstrated that fluoride increased acetylated-p53 and its downstream target <i>p21</i> in ameloblast-derived LS8 cells. However, p21 function in fluoride toxicity is not w...

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Bibliographic Details
Main Authors: Huidan Deng, Atsushi Ikeda, Hengmin Cui, John D. Bartlett, Maiko Suzuki
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
MDM2
p53
p21
ameloblast
fluoride
fluorosis
Online Access:https://www.mdpi.com/2073-4409/8/5/436

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