Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report
Targeted therapies are being increasingly used in clinical practice and trials. However, tumor heterogeneity among sites of metastatic disease can occur creating a conundrum when utilizing biomarker directed therapies. Here we demonstrate a patient with recurrent uterine carcinosarcoma whose local r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578921002083 |
| _version_ | 1818315432062353408 |
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| author | A. ElNaggar N. Zhang C.B. Scalise C. Sirard M.H. Kagey D. Vaena R. Arend |
| author_facet | A. ElNaggar N. Zhang C.B. Scalise C. Sirard M.H. Kagey D. Vaena R. Arend |
| author_sort | A. ElNaggar |
| collection | DOAJ |
| description | Targeted therapies are being increasingly used in clinical practice and trials. However, tumor heterogeneity among sites of metastatic disease can occur creating a conundrum when utilizing biomarker directed therapies. Here we demonstrate a patient with recurrent uterine carcinosarcoma whose local recurrence and metastatic recurrence had a varied response to paclitaxel in combination with DKN-01, a monoclonal antibody against DKK1, a modulator of Wnt/β-catenin and PI3K/AKT signaling pathways. This may be explained by differences in mutational profile found between the two sites. Our findings highlight the importance of analyzing tissue from the primary tumor as well as metastatic lesions, especially if there is a discrepancy in their response to treatment. |
| first_indexed | 2024-12-13T09:05:26Z |
| format | Article |
| id | doaj.art-339a2d4ba545449ba66bb72c38c2d948 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-13T09:05:26Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-339a2d4ba545449ba66bb72c38c2d9482022-12-21T23:53:04ZengElsevierGynecologic Oncology Reports2352-57892022-02-0139100904Response to anti-DKK1 therapy in uterine carcinosarcoma: A case reportA. ElNaggar0N. Zhang1C.B. Scalise2C. Sirard3M.H. Kagey4D. Vaena5R. Arend6Division of Gynecologic Oncology, West Cancer Center and Research Institute, Memphis, TN, USADepartment of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USADivision of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, USALeap Therapeutics, Inc., Cambridge, MA, USALeap Therapeutics, Inc., Cambridge, MA, USADivision of Medical Oncology, West Cancer Center and Research Institute, Memphis, TN, USADivision of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, USA; Corresponding author at: University of Alabama at Birmingham, 619 19th Street South 176F, Rm 10250, Birmingham, AL 35249, USA.Targeted therapies are being increasingly used in clinical practice and trials. However, tumor heterogeneity among sites of metastatic disease can occur creating a conundrum when utilizing biomarker directed therapies. Here we demonstrate a patient with recurrent uterine carcinosarcoma whose local recurrence and metastatic recurrence had a varied response to paclitaxel in combination with DKN-01, a monoclonal antibody against DKK1, a modulator of Wnt/β-catenin and PI3K/AKT signaling pathways. This may be explained by differences in mutational profile found between the two sites. Our findings highlight the importance of analyzing tissue from the primary tumor as well as metastatic lesions, especially if there is a discrepancy in their response to treatment.http://www.sciencedirect.com/science/article/pii/S2352578921002083Tumor heterogeneityUterine carcinosarcomaComprehensive genomic profiling |
| spellingShingle | A. ElNaggar N. Zhang C.B. Scalise C. Sirard M.H. Kagey D. Vaena R. Arend Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report Gynecologic Oncology Reports Tumor heterogeneity Uterine carcinosarcoma Comprehensive genomic profiling |
| title | Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report |
| title_full | Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report |
| title_fullStr | Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report |
| title_full_unstemmed | Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report |
| title_short | Response to anti-DKK1 therapy in uterine carcinosarcoma: A case report |
| title_sort | response to anti dkk1 therapy in uterine carcinosarcoma a case report |
| topic | Tumor heterogeneity Uterine carcinosarcoma Comprehensive genomic profiling |
| url | http://www.sciencedirect.com/science/article/pii/S2352578921002083 |
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