Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure
Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling pro...
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Format: | Article |
Language: | Russian |
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«FIRMA «SILICEA» LLC
2020-11-01
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Series: | Российский кардиологический журнал |
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Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3933 |
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author | T. B. Pecherina A. G. Kutikhin |
author_facet | T. B. Pecherina A. G. Kutikhin |
author_sort | T. B. Pecherina |
collection | DOAJ |
description | Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice. |
first_indexed | 2024-04-09T20:45:25Z |
format | Article |
id | doaj.art-339c05dfd76c4165b6e6f0262b3584a8 |
institution | Directory Open Access Journal |
issn | 1560-4071 2618-7620 |
language | Russian |
last_indexed | 2024-04-09T20:45:25Z |
publishDate | 2020-11-01 |
publisher | «FIRMA «SILICEA» LLC |
record_format | Article |
series | Российский кардиологический журнал |
spelling | doaj.art-339c05dfd76c4165b6e6f0262b3584a82023-03-29T21:23:35Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202020-11-01251010.15829/1560-4071-2020-39333000Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failureT. B. Pecherina0A. G. Kutikhin1Research Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesCurrently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice.https://russjcardiol.elpub.ru/jour/article/view/3933heart failuremyocardial fibrosisbiomarkersgenetic regulation |
spellingShingle | T. B. Pecherina A. G. Kutikhin Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure Российский кардиологический журнал heart failure myocardial fibrosis biomarkers genetic regulation |
title | Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure |
title_full | Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure |
title_fullStr | Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure |
title_full_unstemmed | Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure |
title_short | Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure |
title_sort | biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure |
topic | heart failure myocardial fibrosis biomarkers genetic regulation |
url | https://russjcardiol.elpub.ru/jour/article/view/3933 |
work_keys_str_mv | AT tbpecherina biomarkersofmyocardialfibrosisandtheirgeneticregulationinpatientswithheartfailure AT agkutikhin biomarkersofmyocardialfibrosisandtheirgeneticregulationinpatientswithheartfailure |