Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer
Abstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association bet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-019-6250-8 |
| _version_ | 1819229752547868672 |
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| author | Yuanyuan Xiao Haijun Yang Jian Lu Dehui Li Chuanzhi Xu Harvey A. Risch |
| author_facet | Yuanyuan Xiao Haijun Yang Jian Lu Dehui Li Chuanzhi Xu Harvey A. Risch |
| author_sort | Yuanyuan Xiao |
| collection | DOAJ |
| description | Abstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. Methods We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwestern China. Univariate and multivariate Cox proportional-hazards models were used to determine associations between serum GGT and OS in metastatic PDAC. Results Controlled for possible confounding factors, serum GGT was significantly associated with OS: serum GGT > 48 U/L yielded a hazard ratio of 1.53 (95% CI: 1.19–1.97) for mortality risk. A significant dose-response association between serum GGT and OS was also observed. Subgroup analysis showed a possible interaction between GGT and blood glucose level. Conclusion Serum GGT could be a potential indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated. |
| first_indexed | 2024-12-23T11:18:10Z |
| format | Article |
| id | doaj.art-339da2af96814fbdb3526c0057f02772 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-23T11:18:10Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-339da2af96814fbdb3526c0057f027722022-12-21T17:49:10ZengBMCBMC Cancer1471-24072019-10-011911710.1186/s12885-019-6250-8Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancerYuanyuan Xiao0Haijun Yang1Jian Lu2Dehui Li3Chuanzhi Xu4Harvey A. Risch5School of Public Health, Kunming Medical UniversityThe Third Affiliated Hospital of Kunming Medical UniversityThe Third Affiliated Hospital of Kunming Medical UniversityThe Third Affiliated Hospital of Kunming Medical UniversitySchool of Public Health, Kunming Medical UniversityDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale UniversityAbstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. Methods We identified 320 patients with histopathologically confirmed metastatic pancreatic ductal adenocarcinoma (PDAC) diagnosed during 2015 and 2016 at a specialized cancer hospital in southwestern China. Univariate and multivariate Cox proportional-hazards models were used to determine associations between serum GGT and OS in metastatic PDAC. Results Controlled for possible confounding factors, serum GGT was significantly associated with OS: serum GGT > 48 U/L yielded a hazard ratio of 1.53 (95% CI: 1.19–1.97) for mortality risk. A significant dose-response association between serum GGT and OS was also observed. Subgroup analysis showed a possible interaction between GGT and blood glucose level. Conclusion Serum GGT could be a potential indicator of survival in metastatic PDAC patients. Underlying mechanisms for this association should be investigated.http://link.springer.com/article/10.1186/s12885-019-6250-8BiomarkersPancreatic cancerSurvival |
| spellingShingle | Yuanyuan Xiao Haijun Yang Jian Lu Dehui Li Chuanzhi Xu Harvey A. Risch Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer BMC Cancer Biomarkers Pancreatic cancer Survival |
| title | Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer |
| title_full | Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer |
| title_fullStr | Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer |
| title_full_unstemmed | Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer |
| title_short | Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer |
| title_sort | serum gamma glutamyltransferase and the overall survival of metastatic pancreatic cancer |
| topic | Biomarkers Pancreatic cancer Survival |
| url | http://link.springer.com/article/10.1186/s12885-019-6250-8 |
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