Perinatal inflammation influences but does not arrest rapid immune development in preterm babies
The infant immune system is continuously shaped by environmental factors. Here the authors demonstrate that rapid immune development in preterm babies is modulated by perinatal inflammation more than gut microbiota, and that lower CXCL8-producing T cells may identify infants susceptible to infection...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14923-8 |
| _version_ | 1818422652428091392 |
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| author | S. Kamdar R. Hutchinson A. Laing F. Stacey K. Ansbro M. R. Millar K. Costeloe W. G. Wade P. Fleming D. L. Gibbons |
| author_facet | S. Kamdar R. Hutchinson A. Laing F. Stacey K. Ansbro M. R. Millar K. Costeloe W. G. Wade P. Fleming D. L. Gibbons |
| author_sort | S. Kamdar |
| collection | DOAJ |
| description | The infant immune system is continuously shaped by environmental factors. Here the authors demonstrate that rapid immune development in preterm babies is modulated by perinatal inflammation more than gut microbiota, and that lower CXCL8-producing T cells may identify infants susceptible to infection. |
| first_indexed | 2024-12-14T13:29:39Z |
| format | Article |
| id | doaj.art-339db50187574d0b809b573991bf232a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:29:39Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-339db50187574d0b809b573991bf232a2022-12-21T22:59:44ZengNature PortfolioNature Communications2041-17232020-03-0111111410.1038/s41467-020-14923-8Perinatal inflammation influences but does not arrest rapid immune development in preterm babiesS. Kamdar0R. Hutchinson1A. Laing2F. Stacey3K. Ansbro4M. R. Millar5K. Costeloe6W. G. Wade7P. Fleming8D. L. Gibbons9Peter Gorer Department of Immunobiology, King’s College LondonDepartment of Neonatology, Homerton University HospitalPeter Gorer Department of Immunobiology, King’s College LondonDepartment of Neonatology, Homerton University HospitalBarts and the London School of Medicine and Dentistry, Queen Mary University of LondonBarts and the London School of Medicine and Dentistry, Queen Mary University of LondonBarts and the London School of Medicine and Dentistry, Queen Mary University of LondonFaculty of Dentistry, Oral and Craniofacial Sciences, Centre for Host-Microbiome Interactions, King’s College LondonDepartment of Neonatology, Homerton University HospitalPeter Gorer Department of Immunobiology, King’s College LondonThe infant immune system is continuously shaped by environmental factors. Here the authors demonstrate that rapid immune development in preterm babies is modulated by perinatal inflammation more than gut microbiota, and that lower CXCL8-producing T cells may identify infants susceptible to infection.https://doi.org/10.1038/s41467-020-14923-8 |
| spellingShingle | S. Kamdar R. Hutchinson A. Laing F. Stacey K. Ansbro M. R. Millar K. Costeloe W. G. Wade P. Fleming D. L. Gibbons Perinatal inflammation influences but does not arrest rapid immune development in preterm babies Nature Communications |
| title | Perinatal inflammation influences but does not arrest rapid immune development in preterm babies |
| title_full | Perinatal inflammation influences but does not arrest rapid immune development in preterm babies |
| title_fullStr | Perinatal inflammation influences but does not arrest rapid immune development in preterm babies |
| title_full_unstemmed | Perinatal inflammation influences but does not arrest rapid immune development in preterm babies |
| title_short | Perinatal inflammation influences but does not arrest rapid immune development in preterm babies |
| title_sort | perinatal inflammation influences but does not arrest rapid immune development in preterm babies |
| url | https://doi.org/10.1038/s41467-020-14923-8 |
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