Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study
BackgroundBasal metabolic rate (BMR) is the minimum amount of energy needed by the body to carry out essential physiological functions. The goal of this study was to evaluate whether BMR causally influences venous thromboembolism (VTE) and its subtypes in European individuals.MethodsA two-sample Men...
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1263804/full |
| _version_ | 1827577796803690496 |
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| author | Jian Huang Yubo Xie Yubo Xie |
| author_facet | Jian Huang Yubo Xie Yubo Xie |
| author_sort | Jian Huang |
| collection | DOAJ |
| description | BackgroundBasal metabolic rate (BMR) is the minimum amount of energy needed by the body to carry out essential physiological functions. The goal of this study was to evaluate whether BMR causally influences venous thromboembolism (VTE) and its subtypes in European individuals.MethodsA two-sample Mendelian randomization (MR) was performed. Within a genome-wide association study (GWAS) involving 454,874 people, genetic variants were chosen as instrumental variables based on their significant associations (p < 5 × 10−8) with BMR and their limited linkage disequilibrium (r2 < 0.001). The FinnGen project served as sources for summary statistics of VTE, encompassing different subtypes.ResultsUsing the multiplicative random-effect inverse variance weighted method, our investigation revealed that one standard deviation higher BMR was associated with VTE (odds ratio [OR] = 1.684, 95% confidence interval [CI]: 1.465–1.936, p = 2.339 × 10−13), PE (OR = 1.824, 95% CI: 1.512–2.200, p = 3.399 × 10−10), and DVT of lower extremities (OR = 1.887, 95% CI: 1.562–2.280, p = 4.778 × 10−11). The consistency of these associations was observed in sensitivity analyses using various MR techniques like Mendelian randomization pleiotropy residual sum and outlier, MR-Egger, weighted median, and contamination mixture method. In addition, multivariable MR revealed direct effects of BMR on VTE and its subtypes when taking body mass index and current tobacco smoking into account.ConclusionHigher BMR may increase the risk of VTE and its subtypes including PE and DVT of lower extremities. |
| first_indexed | 2024-03-08T21:32:58Z |
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| id | doaj.art-339edaaf1ac844f49c73f8a3a15e9e2d |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-08T21:32:58Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-339edaaf1ac844f49c73f8a3a15e9e2d2023-12-21T04:29:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-12-011010.3389/fnut.2023.12638041263804Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization studyJian Huang0Yubo Xie1Yubo Xie2Clinical Laboratory Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaBackgroundBasal metabolic rate (BMR) is the minimum amount of energy needed by the body to carry out essential physiological functions. The goal of this study was to evaluate whether BMR causally influences venous thromboembolism (VTE) and its subtypes in European individuals.MethodsA two-sample Mendelian randomization (MR) was performed. Within a genome-wide association study (GWAS) involving 454,874 people, genetic variants were chosen as instrumental variables based on their significant associations (p < 5 × 10−8) with BMR and their limited linkage disequilibrium (r2 < 0.001). The FinnGen project served as sources for summary statistics of VTE, encompassing different subtypes.ResultsUsing the multiplicative random-effect inverse variance weighted method, our investigation revealed that one standard deviation higher BMR was associated with VTE (odds ratio [OR] = 1.684, 95% confidence interval [CI]: 1.465–1.936, p = 2.339 × 10−13), PE (OR = 1.824, 95% CI: 1.512–2.200, p = 3.399 × 10−10), and DVT of lower extremities (OR = 1.887, 95% CI: 1.562–2.280, p = 4.778 × 10−11). The consistency of these associations was observed in sensitivity analyses using various MR techniques like Mendelian randomization pleiotropy residual sum and outlier, MR-Egger, weighted median, and contamination mixture method. In addition, multivariable MR revealed direct effects of BMR on VTE and its subtypes when taking body mass index and current tobacco smoking into account.ConclusionHigher BMR may increase the risk of VTE and its subtypes including PE and DVT of lower extremities.https://www.frontiersin.org/articles/10.3389/fnut.2023.1263804/fullbasal metabolic ratevenous thromboembolismdeep vein thrombosis of lower extremitiespulmonary embolismMendelian randomization |
| spellingShingle | Jian Huang Yubo Xie Yubo Xie Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study Frontiers in Nutrition basal metabolic rate venous thromboembolism deep vein thrombosis of lower extremities pulmonary embolism Mendelian randomization |
| title | Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study |
| title_full | Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study |
| title_fullStr | Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study |
| title_full_unstemmed | Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study |
| title_short | Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study |
| title_sort | genetically predicted basal metabolic rate and venous thromboembolism risk a mendelian randomization study |
| topic | basal metabolic rate venous thromboembolism deep vein thrombosis of lower extremities pulmonary embolism Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1263804/full |
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