Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol
Limited epidemiological evidence suggests a link between antibiotic use and developing depression. This study seeks to investigate this association in depth, using a cohort of pregnant individuals. The primary aim is to explore any association between the use of antibiotics during pregnancy and the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Methods and Protocols |
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| Online Access: | https://www.mdpi.com/2409-9279/6/5/98 |
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| author | Mahsa Pouranayatihosseinabad Maggie Taylor Jason Hawrelak Gregory M. Peterson Felicity Veal Tristan Ling Mackenzie Williams Megan Whatley Kyan Ahdieh Corinne Mirkazemi |
| author_facet | Mahsa Pouranayatihosseinabad Maggie Taylor Jason Hawrelak Gregory M. Peterson Felicity Veal Tristan Ling Mackenzie Williams Megan Whatley Kyan Ahdieh Corinne Mirkazemi |
| author_sort | Mahsa Pouranayatihosseinabad |
| collection | DOAJ |
| description | Limited epidemiological evidence suggests a link between antibiotic use and developing depression. This study seeks to investigate this association in depth, using a cohort of pregnant individuals. The primary aim is to explore any association between the use of antibiotics during pregnancy and the development of antenatal depressive symptoms up to the third trimester, as well as the use of antibiotics during pregnancy and within 12 months postpartum and the development of postpartum depressive symptoms. A national prospective, observational, longitudinal cohort study has been designed to examine these relationships. A sample size of 1500 pregnant individuals has been sought for this study, assuming 10 potential predictor variables (including antibiotic use) in the final multiple logistic regression model and allowing for a 30% drop-out rate. The development of depressive symptoms is considered either a diagnosis by a medical doctor and/or a scoring 13 or higher on the Edinburgh Postnatal Depression Scale. Data will be collected during the third trimester and at 6 weeks, 6 months, and 12 months postpartum. These surveys include variables previously identified as associated with antenatal and postpartum depression (e.g., level of social support, experience of intimate partner abuse, and obstetric complications), as well as antibiotic and probiotic use. This study will provide an update on the prevalence of the symptoms of depression during pregnancy and postpartum and its associated risk factors. It will also, for the first time, comprehensively explore the potential association between antibiotic use during pregnancy and up to 12 months postpartum and the development of depressive symptoms. |
| first_indexed | 2024-03-10T21:00:26Z |
| format | Article |
| id | doaj.art-339eedaa3ea148af8ae6dcc8b7c62356 |
| institution | Directory Open Access Journal |
| issn | 2409-9279 |
| language | English |
| last_indexed | 2024-03-10T21:00:26Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Methods and Protocols |
| spelling | doaj.art-339eedaa3ea148af8ae6dcc8b7c623562023-11-19T17:35:08ZengMDPI AGMethods and Protocols2409-92792023-10-01659810.3390/mps6050098Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study ProtocolMahsa Pouranayatihosseinabad0Maggie Taylor1Jason Hawrelak2Gregory M. Peterson3Felicity Veal4Tristan Ling5Mackenzie Williams6Megan Whatley7Kyan Ahdieh8Corinne Mirkazemi9School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaDepartment of Obstetrics and Gynaecology, Royal Hobart Hospital, Hobart, TAS 7000, AustraliaLaunceston Medical Centre, Health Hub, Launceston, TAS 7250, AustraliaSchool of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7005, AustraliaLimited epidemiological evidence suggests a link between antibiotic use and developing depression. This study seeks to investigate this association in depth, using a cohort of pregnant individuals. The primary aim is to explore any association between the use of antibiotics during pregnancy and the development of antenatal depressive symptoms up to the third trimester, as well as the use of antibiotics during pregnancy and within 12 months postpartum and the development of postpartum depressive symptoms. A national prospective, observational, longitudinal cohort study has been designed to examine these relationships. A sample size of 1500 pregnant individuals has been sought for this study, assuming 10 potential predictor variables (including antibiotic use) in the final multiple logistic regression model and allowing for a 30% drop-out rate. The development of depressive symptoms is considered either a diagnosis by a medical doctor and/or a scoring 13 or higher on the Edinburgh Postnatal Depression Scale. Data will be collected during the third trimester and at 6 weeks, 6 months, and 12 months postpartum. These surveys include variables previously identified as associated with antenatal and postpartum depression (e.g., level of social support, experience of intimate partner abuse, and obstetric complications), as well as antibiotic and probiotic use. This study will provide an update on the prevalence of the symptoms of depression during pregnancy and postpartum and its associated risk factors. It will also, for the first time, comprehensively explore the potential association between antibiotic use during pregnancy and up to 12 months postpartum and the development of depressive symptoms.https://www.mdpi.com/2409-9279/6/5/98antenatalantenatal depressionantibioticassociationdepressionmental health |
| spellingShingle | Mahsa Pouranayatihosseinabad Maggie Taylor Jason Hawrelak Gregory M. Peterson Felicity Veal Tristan Ling Mackenzie Williams Megan Whatley Kyan Ahdieh Corinne Mirkazemi Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol Methods and Protocols antenatal antenatal depression antibiotic association depression mental health |
| title | Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol |
| title_full | Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol |
| title_fullStr | Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol |
| title_full_unstemmed | Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol |
| title_short | Maternal Antibiotic Exposure and the Risk of Developing Antenatal or Postpartum Depressive Symptoms: The Maternal Experience Study Protocol |
| title_sort | maternal antibiotic exposure and the risk of developing antenatal or postpartum depressive symptoms the maternal experience study protocol |
| topic | antenatal antenatal depression antibiotic association depression mental health |
| url | https://www.mdpi.com/2409-9279/6/5/98 |
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