Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel
Silica aerogel, a kind of nanoporous material, is regarded as a desired drug carrier for its low toxicity, high specific surface area, and excellent biocompatibility. Using silica aerogel in a drug carrier may be an appropriate method to improve the performance of pure resveratrol. In this study, re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/12/2752 |
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| author | Lili Qin Yiwei He Xinyu Zhao Ting Zhang Yao Qin Ai Du |
| author_facet | Lili Qin Yiwei He Xinyu Zhao Ting Zhang Yao Qin Ai Du |
| author_sort | Lili Qin |
| collection | DOAJ |
| description | Silica aerogel, a kind of nanoporous material, is regarded as a desired drug carrier for its low toxicity, high specific surface area, and excellent biocompatibility. Using silica aerogel in a drug carrier may be an appropriate method to improve the performance of pure resveratrol. In this study, resveratrol-loaded silica aerogel (RSA) as a drug delivery system was prepared by the sol-gel method. Before gelling, resveratrol was added into the hydrolyzed tetraethyl orthosilicate (TEOS) ethanol solution then dispersed by stir and ultrasound. The results showed that RSA has a high loading rate of 19% with low cost and excellent biocompatibility. The SEM images showed that silica aerogel wraps up outside the resveratrol. Sustained releasing effect could be observed in RSA after 1 h, while pure resveratrol did not display this. The release of RSA lasted for over 6 h, and the release amount reached over 90% and 80% in either simulated gastric fluid (pH = 2.0) or phosphate-buffered saline (pH = 7.4) at 37 °C. Preliminary in vitro toxicity test revealed RSA to be biocompatible and stable; and when coupled with the anti-inflammatory effects of resveratrol, showed good potential for osteoarthritis treatment. |
| first_indexed | 2024-03-10T19:09:57Z |
| format | Article |
| id | doaj.art-339f54bc4ed54f8a81781fa7e828b150 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:09:57Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-339f54bc4ed54f8a81781fa7e828b1502023-11-20T03:50:29ZengMDPI AGMolecules1420-30492020-06-012512275210.3390/molecules25122752Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica AerogelLili Qin0Yiwei He1Xinyu Zhao2Ting Zhang3Yao Qin4Ai Du5Sports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, ChinaSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, ChinaSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, ChinaSilica aerogel, a kind of nanoporous material, is regarded as a desired drug carrier for its low toxicity, high specific surface area, and excellent biocompatibility. Using silica aerogel in a drug carrier may be an appropriate method to improve the performance of pure resveratrol. In this study, resveratrol-loaded silica aerogel (RSA) as a drug delivery system was prepared by the sol-gel method. Before gelling, resveratrol was added into the hydrolyzed tetraethyl orthosilicate (TEOS) ethanol solution then dispersed by stir and ultrasound. The results showed that RSA has a high loading rate of 19% with low cost and excellent biocompatibility. The SEM images showed that silica aerogel wraps up outside the resveratrol. Sustained releasing effect could be observed in RSA after 1 h, while pure resveratrol did not display this. The release of RSA lasted for over 6 h, and the release amount reached over 90% and 80% in either simulated gastric fluid (pH = 2.0) or phosphate-buffered saline (pH = 7.4) at 37 °C. Preliminary in vitro toxicity test revealed RSA to be biocompatible and stable; and when coupled with the anti-inflammatory effects of resveratrol, showed good potential for osteoarthritis treatment.https://www.mdpi.com/1420-3049/25/12/2752resveratrolsilica aerogeldrug carriercharacterizationrelease kinetics |
| spellingShingle | Lili Qin Yiwei He Xinyu Zhao Ting Zhang Yao Qin Ai Du Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel Molecules resveratrol silica aerogel drug carrier characterization release kinetics |
| title | Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel |
| title_full | Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel |
| title_fullStr | Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel |
| title_full_unstemmed | Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel |
| title_short | Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel |
| title_sort | preparation characterization and in vitro sustained release profile of resveratrol loaded silica aerogel |
| topic | resveratrol silica aerogel drug carrier characterization release kinetics |
| url | https://www.mdpi.com/1420-3049/25/12/2752 |
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