Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

α-Synuclein plays a central role in the pathogenesis of Parkinson's disease (PD); interventions that decrease its expression appear neuroprotective in PD models. Successful translation of these observations into effective therapies will be dependent on the safety of suppressing α-synuclein expr...

Full description

Bibliographic Details
Main Authors: Alevtina Zharikov, Qing Bai, Briana R. De Miranda, Amber Van Laar, J. Timothy Greenamyre, Edward A. Burton
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305606

Similar Items

Similar Items