Preclinical deposition of pathological prion protein in muscle of experimentally infected primates.

Preclinical deposition of pathological prion protein in muscle of experimentally infected primates.

Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and animals. A central step in disease progression is the accumulation of a misfolded form (PrP(Sc)) of the host encoded prion protein (PrP(C)) in neuronal and non-neuronal tissues. The involvement of peripheral tiss...

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Bibliographic Details
Main Authors: Susanne Krasemann, Melanie Neumann, Markus Geissen, Walter Bodemer, Franz-Josef Kaup, Walter Schulz-Schaeffer, Nathalie Morel, Adriano Aguzzi, Markus Glatzel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2978702?pdf=render

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