Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan
Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118217300609 |
| _version_ | 1811283049720053760 |
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| author | Kai-Wen Wu Shih-Min Wang Ching-Fen Shen Tzong-Shiann Ho Jen-Ren Wang Ching-Chuan Liu |
| author_facet | Kai-Wen Wu Shih-Min Wang Ching-Fen Shen Tzong-Shiann Ho Jen-Ren Wang Ching-Chuan Liu |
| author_sort | Kai-Wen Wu |
| collection | DOAJ |
| description | Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throat swab or nasopharyngeal aspirates at a tertiary care university hospital, between January 2012 and December 2014. HPIV4 was not checked and analyzed, due to not include in the commercial kit. The demographic, epidemiological, clinical presentations, diagnosis, treatment, outcomes, and laboratory data were analyzed. Results: Totally 398 cases were enrolled, including 39 (9.8%) of HPIV1, 67 (16.8%) of HPIV2, and 292 (73.4%) of HPIV3. The mean age of HPIV-infected children was 2.9 year-old, and 50.5% were among one to three year-old. A total of 56.8% HPIV3-infected children were among one to three years old, however, no HPIV2-infected children was younger than one year-old. The HPIV1-infected patients were more common to develop wheezing and diagnose as acute bronchiolitis. HPIV2-infected children were more likely to have hoarseness (23.9%), and were associated with croup (25.4%). HPIV3 was isolated from two fatal cases, with neurological underlying diseases. Conclusion: The impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management. Keywords: Parainfluenza viruses, Acute bronchiolitis, Croup, Children, Taiwan |
| first_indexed | 2024-04-13T02:03:35Z |
| format | Article |
| id | doaj.art-33a19ffa84034337be205912e67d4471 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-13T02:03:35Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-33a19ffa84034337be205912e67d44712022-12-22T03:07:31ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822018-12-01516749755Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern TaiwanKai-Wen Wu0Shih-Min Wang1Ching-Fen Shen2Tzong-Shiann Ho3Jen-Ren Wang4Ching-Chuan Liu5Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, TaiwanDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan; Corresponding author. Department of Pediatrics, National Cheng Kung University Hospital, No.138, Sheng-Li Road, Tainan City 70403, Taiwan. Fax: +886 6 2753083.Background: Human parainfluenza viruses (HPIV) 1–4 had been analyzed as being one of the most frequent causes of hospitalizations for young children with respiratory tract illnesses. Methods: This retrospective study was performed from children virologically confirmed as HPIV infection through throat swab or nasopharyngeal aspirates at a tertiary care university hospital, between January 2012 and December 2014. HPIV4 was not checked and analyzed, due to not include in the commercial kit. The demographic, epidemiological, clinical presentations, diagnosis, treatment, outcomes, and laboratory data were analyzed. Results: Totally 398 cases were enrolled, including 39 (9.8%) of HPIV1, 67 (16.8%) of HPIV2, and 292 (73.4%) of HPIV3. The mean age of HPIV-infected children was 2.9 year-old, and 50.5% were among one to three year-old. A total of 56.8% HPIV3-infected children were among one to three years old, however, no HPIV2-infected children was younger than one year-old. The HPIV1-infected patients were more common to develop wheezing and diagnose as acute bronchiolitis. HPIV2-infected children were more likely to have hoarseness (23.9%), and were associated with croup (25.4%). HPIV3 was isolated from two fatal cases, with neurological underlying diseases. Conclusion: The impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management. Keywords: Parainfluenza viruses, Acute bronchiolitis, Croup, Children, Taiwanhttp://www.sciencedirect.com/science/article/pii/S1684118217300609 |
| spellingShingle | Kai-Wen Wu Shih-Min Wang Ching-Fen Shen Tzong-Shiann Ho Jen-Ren Wang Ching-Chuan Liu Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan Journal of Microbiology, Immunology and Infection |
| title | Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan |
| title_full | Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan |
| title_fullStr | Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan |
| title_full_unstemmed | Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan |
| title_short | Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan |
| title_sort | clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S1684118217300609 |
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