Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy
Background: Prealbumin is a marker of malnutrition and inflammation. It has been associated with poor prognosis in cardiovascular disease, but less is known in stroke patients. Our objective was to evaluate the association of prealbumin levels at admission with prognosis in patients with stroke trea...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-08-01
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| Series: | Cerebrovascular Diseases Extra |
| Online Access: | https://www.karger.com/Article/FullText/526354 |
| _version_ | 1828405127125401600 |
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| author | Begoña López Maria Castañón-Apilánez Javier Molina-Gil Santiago Fernández-Gordón Sánchez Gemma González Antía Reguera Acuña Jose Maria Jimenez Davinia Larrosa Campo Montserrat González Delgado Lorena Benavente-Fernández Maria Rico-Santos Carmen García-Cabo Sergio Calleja Puerta Elena López-Cancio |
| author_facet | Begoña López Maria Castañón-Apilánez Javier Molina-Gil Santiago Fernández-Gordón Sánchez Gemma González Antía Reguera Acuña Jose Maria Jimenez Davinia Larrosa Campo Montserrat González Delgado Lorena Benavente-Fernández Maria Rico-Santos Carmen García-Cabo Sergio Calleja Puerta Elena López-Cancio |
| author_sort | Begoña López |
| collection | DOAJ |
| description | Background: Prealbumin is a marker of malnutrition and inflammation. It has been associated with poor prognosis in cardiovascular disease, but less is known in stroke patients. Our objective was to evaluate the association of prealbumin levels at admission with prognosis in patients with stroke treated with mechanical thrombectomy. Material & Methods: Retrospective study of a prospective database of consecutive patients treated with mechanical thrombectomy. Clinical, radiological and blood parameters including serum prealbumin, and prognostic variables such as respiratory infection, in-hospital mortality, and modified Rankin scale at 3 months were collected. Results: We included 319 patients between 2018-2019. Prealbumin levels were significantly lower in patients older than 80 years, women, patients with a prestroke Rankin score >2, glomerular filtrate rate 2), in-hospital mortality and 3-month mortality. In multivariate analysis, prealbumin was an independent risk factor associated with mortality at 3 months, OR 0.92 [0.86-0.98], p = 0.019. Conclusion: Lower prealbumin levels at admission behaved as independent predictor of long-term mortality in patients treated with mechanical thrombectomy. These results should be replicated in other cohorts. |
| first_indexed | 2024-12-10T10:48:54Z |
| format | Article |
| id | doaj.art-33a293c126fb4433a0a89ab285b7ed12 |
| institution | Directory Open Access Journal |
| issn | 1664-5456 |
| language | English |
| last_indexed | 2024-12-10T10:48:54Z |
| publishDate | 2022-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Cerebrovascular Diseases Extra |
| spelling | doaj.art-33a293c126fb4433a0a89ab285b7ed122022-12-22T01:52:05ZengKarger PublishersCerebrovascular Diseases Extra1664-54562022-08-0110.1159/000526354526354Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomyBegoña Lópezhttps://orcid.org/0000-0002-4065-1487Maria Castañón-ApilánezJavier Molina-GilSantiago Fernández-Gordón SánchezGemma GonzálezAntía Reguera Acuñahttps://orcid.org/0000-0002-4963-2856Jose Maria JimenezDavinia Larrosa CampoMontserrat González Delgadohttps://orcid.org/0000-0002-7612-6502Lorena Benavente-FernándezMaria Rico-SantosCarmen García-CaboSergio Calleja Puertahttps://orcid.org/0000-0002-9050-6771Elena López-Canciohttps://orcid.org/0000-0001-5757-9074Background: Prealbumin is a marker of malnutrition and inflammation. It has been associated with poor prognosis in cardiovascular disease, but less is known in stroke patients. Our objective was to evaluate the association of prealbumin levels at admission with prognosis in patients with stroke treated with mechanical thrombectomy. Material & Methods: Retrospective study of a prospective database of consecutive patients treated with mechanical thrombectomy. Clinical, radiological and blood parameters including serum prealbumin, and prognostic variables such as respiratory infection, in-hospital mortality, and modified Rankin scale at 3 months were collected. Results: We included 319 patients between 2018-2019. Prealbumin levels were significantly lower in patients older than 80 years, women, patients with a prestroke Rankin score >2, glomerular filtrate rate 2), in-hospital mortality and 3-month mortality. In multivariate analysis, prealbumin was an independent risk factor associated with mortality at 3 months, OR 0.92 [0.86-0.98], p = 0.019. Conclusion: Lower prealbumin levels at admission behaved as independent predictor of long-term mortality in patients treated with mechanical thrombectomy. These results should be replicated in other cohorts.https://www.karger.com/Article/FullText/526354 |
| spellingShingle | Begoña López Maria Castañón-Apilánez Javier Molina-Gil Santiago Fernández-Gordón Sánchez Gemma González Antía Reguera Acuña Jose Maria Jimenez Davinia Larrosa Campo Montserrat González Delgado Lorena Benavente-Fernández Maria Rico-Santos Carmen García-Cabo Sergio Calleja Puerta Elena López-Cancio Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy Cerebrovascular Diseases Extra |
| title | Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy |
| title_full | Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy |
| title_fullStr | Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy |
| title_full_unstemmed | Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy |
| title_short | Serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy |
| title_sort | serum prealbumin levels on admission as a prognostic marker in stroke patients treated with mechanical thrombectomy |
| url | https://www.karger.com/Article/FullText/526354 |
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