Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial
We aimed to evaluate diffusion tensor imaging (DTI) in infants born extremely preterm, to determine the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Infants who...
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MDPI AG
2021-10-01
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| Online Access: | https://www.mdpi.com/2076-3425/11/10/1360 |
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| author | Janessa B. Law Bryan A. Comstock Todd L. Richards Christopher M. Traudt Thomas R. Wood Dennis E. Mayock Patrick J. Heagerty Sandra E. Juul |
| author_facet | Janessa B. Law Bryan A. Comstock Todd L. Richards Christopher M. Traudt Thomas R. Wood Dennis E. Mayock Patrick J. Heagerty Sandra E. Juul |
| author_sort | Janessa B. Law |
| collection | DOAJ |
| description | We aimed to evaluate diffusion tensor imaging (DTI) in infants born extremely preterm, to determine the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Infants who underwent MRI with DTI at 36 weeks postmenstrual age were included. Neurodevelopmental outcomes were evaluated by Bayley Scales of Infant and Toddler Development (BSID-III). Generalized linear models were used to assess the association between DTI parameters and treatment group, and then with neurodevelopmental outcomes. A total of 101 placebo- and 93 Epo-treated infants underwent MRI. DTI white matter mean diffusivity (MD) was lower in placebo- compared to Epo-treated infants in the cingulate and occipital regions, and occipital white matter fractional isotropy (FA) was lower in infants born at 24–25 weeks vs. 26–27 weeks. These values were not associated with lower BSID-III scores. Certain decreases in clustering coefficients tended to have lower BSID-III scores. Consistent with the PENUT Trial findings, there was no effect on long-term neurodevelopment in Epo-treated infants even in the presence of microstructural changes identified by DTI. |
| first_indexed | 2024-03-10T06:41:14Z |
| format | Article |
| id | doaj.art-33a295dab522438eb82257c4160ed536 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T06:41:14Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-33a295dab522438eb82257c4160ed5362023-11-22T17:38:00ZengMDPI AGBrain Sciences2076-34252021-10-011110136010.3390/brainsci11101360Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection TrialJanessa B. Law0Bryan A. Comstock1Todd L. Richards2Christopher M. Traudt3Thomas R. Wood4Dennis E. Mayock5Patrick J. Heagerty6Sandra E. Juul7Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195, USADepartment of Biostatistics, University of Washington, Seattle, WA 98195, USADepartment of Radiology, University of Washington, Seattle, WA 98195, USADivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195, USADivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195, USADivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195, USADepartment of Biostatistics, University of Washington, Seattle, WA 98195, USADivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195, USAWe aimed to evaluate diffusion tensor imaging (DTI) in infants born extremely preterm, to determine the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants in the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Infants who underwent MRI with DTI at 36 weeks postmenstrual age were included. Neurodevelopmental outcomes were evaluated by Bayley Scales of Infant and Toddler Development (BSID-III). Generalized linear models were used to assess the association between DTI parameters and treatment group, and then with neurodevelopmental outcomes. A total of 101 placebo- and 93 Epo-treated infants underwent MRI. DTI white matter mean diffusivity (MD) was lower in placebo- compared to Epo-treated infants in the cingulate and occipital regions, and occipital white matter fractional isotropy (FA) was lower in infants born at 24–25 weeks vs. 26–27 weeks. These values were not associated with lower BSID-III scores. Certain decreases in clustering coefficients tended to have lower BSID-III scores. Consistent with the PENUT Trial findings, there was no effect on long-term neurodevelopment in Epo-treated infants even in the presence of microstructural changes identified by DTI.https://www.mdpi.com/2076-3425/11/10/1360diffusion tensor imagingpretermerythropoietinclustering coefficient |
| spellingShingle | Janessa B. Law Bryan A. Comstock Todd L. Richards Christopher M. Traudt Thomas R. Wood Dennis E. Mayock Patrick J. Heagerty Sandra E. Juul Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial Brain Sciences diffusion tensor imaging preterm erythropoietin clustering coefficient |
| title | Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial |
| title_full | Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial |
| title_fullStr | Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial |
| title_full_unstemmed | Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial |
| title_short | Diffusion Tensor Imaging Changes Do Not Affect Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants in the Preterm Erythropoietin Neuroprotection Trial |
| title_sort | diffusion tensor imaging changes do not affect long term neurodevelopment following early erythropoietin among extremely preterm infants in the preterm erythropoietin neuroprotection trial |
| topic | diffusion tensor imaging preterm erythropoietin clustering coefficient |
| url | https://www.mdpi.com/2076-3425/11/10/1360 |
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