Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its own recept...

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Bibliographic Details
Main Authors: Zhigang Shi, Nicole E Pelletier, Jennifer Wong, Baoxin Li, Andrei D Sdrulla, Christopher J Madden, Daniel L Marks, Virginia L Brooks
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
sympathetic nerve activity
paraventricular nucleus
brown adipose tissue
glutamatergic neurons
thyrotropin releasing hormone
leptin
Online Access:https://elifesciences.org/articles/55357

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