Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that PVN leptin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its own recept...

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Podrobná bibliografie
Hlavní autoři: Zhigang Shi, Nicole E Pelletier, Jennifer Wong, Baoxin Li, Andrei D Sdrulla, Christopher J Madden, Daniel L Marks, Virginia L Brooks
Médium: Článek
Jazyk:English
Vydáno: eLife Sciences Publications Ltd 2020-06-01
Edice:eLife
Témata:
sympathetic nerve activity
paraventricular nucleus
brown adipose tissue
glutamatergic neurons
thyrotropin releasing hormone
leptin
On-line přístup:https://elifesciences.org/articles/55357

Internet

https://elifesciences.org/articles/55357

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