Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart
Background: The immunization of healthcare workers (HCWs) plays a recognized key role in prevention in the COVID-19 pandemic: in Italy, the vaccination campaign began at the end of December 2020. A better knowledge of the on-field immune response in HCWs, of adverse effects and of the main factors i...
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MDPI AG
2021-06-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/6/652 |
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| author | Alberto Modenese Stefania Paduano Annalisa Bargellini Rossana Bellucci Simona Marchetti Fulvio Bruno Pietro Grazioli Roberto Vivoli Fabriziomaria Gobba |
| author_facet | Alberto Modenese Stefania Paduano Annalisa Bargellini Rossana Bellucci Simona Marchetti Fulvio Bruno Pietro Grazioli Roberto Vivoli Fabriziomaria Gobba |
| author_sort | Alberto Modenese |
| collection | DOAJ |
| description | Background: The immunization of healthcare workers (HCWs) plays a recognized key role in prevention in the COVID-19 pandemic: in Italy, the vaccination campaign began at the end of December 2020. A better knowledge of the on-field immune response in HCWs, of adverse effects and of the main factors involved is fundamental. Methods: We performed a study on workers at a nursing home in Northern Italy, vaccinated in January–February 2021 with two doses of the BNT162b2 vaccine four weeks apart, instead of the three weeks provided for in the original manufacturer protocol. One month after the second dose, the serological titer of IgG-neutralizing anti-RBD antibodies of the subunit S1 of the spike protein of SARS-CoV-2 was determined. The socio-demographic and clinical characteristics of the subjects and adverse effects of vaccination were collected by questionnaire. Results: In all of the workers, high antibody titer, ranging between 20 and 760 times the minimum protective level were observed. Titers were significantly higher in subjects with a previous COVID-19 diagnosis. Adverse effects after the vaccine were more frequent after the second dose, but no severe adverse effects were observed. Conclusions: The two doses of the BNT162b2 vaccine, even if administered four weeks apart, induced high titers of anti-SARS-CoV-2 neutralizing IgG in all the operators included in the study. |
| first_indexed | 2024-03-10T10:24:11Z |
| format | Article |
| id | doaj.art-33a514edb64a415dbe0d70acd11cd4da |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T10:24:11Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-33a514edb64a415dbe0d70acd11cd4da2023-11-22T00:07:53ZengMDPI AGVaccines2076-393X2021-06-019665210.3390/vaccines9060652Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks ApartAlberto Modenese0Stefania Paduano1Annalisa Bargellini2Rossana Bellucci3Simona Marchetti4Fulvio Bruno5Pietro Grazioli6Roberto Vivoli7Fabriziomaria Gobba8Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, ItalyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, ItalyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, ItalyLaboratorio Analisi TEST SrL, 41121 Modena, ItalyLaboratorio Analisi TEST SrL, 41121 Modena, ItalyFondazione Scarpari Forattini Onlus, 46020 Schivenoglia, MN, ItalyFondazione Scarpari Forattini Onlus, 46020 Schivenoglia, MN, ItalyLaboratorio Analisi TEST SrL, 41121 Modena, ItalyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, 41125 Modena, ItalyBackground: The immunization of healthcare workers (HCWs) plays a recognized key role in prevention in the COVID-19 pandemic: in Italy, the vaccination campaign began at the end of December 2020. A better knowledge of the on-field immune response in HCWs, of adverse effects and of the main factors involved is fundamental. Methods: We performed a study on workers at a nursing home in Northern Italy, vaccinated in January–February 2021 with two doses of the BNT162b2 vaccine four weeks apart, instead of the three weeks provided for in the original manufacturer protocol. One month after the second dose, the serological titer of IgG-neutralizing anti-RBD antibodies of the subunit S1 of the spike protein of SARS-CoV-2 was determined. The socio-demographic and clinical characteristics of the subjects and adverse effects of vaccination were collected by questionnaire. Results: In all of the workers, high antibody titer, ranging between 20 and 760 times the minimum protective level were observed. Titers were significantly higher in subjects with a previous COVID-19 diagnosis. Adverse effects after the vaccine were more frequent after the second dose, but no severe adverse effects were observed. Conclusions: The two doses of the BNT162b2 vaccine, even if administered four weeks apart, induced high titers of anti-SARS-CoV-2 neutralizing IgG in all the operators included in the study.https://www.mdpi.com/2076-393X/9/6/652SARS-CoV-2COVID-19healthcare workersvaccinesantibody titeradverse effects |
| spellingShingle | Alberto Modenese Stefania Paduano Annalisa Bargellini Rossana Bellucci Simona Marchetti Fulvio Bruno Pietro Grazioli Roberto Vivoli Fabriziomaria Gobba Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart Vaccines SARS-CoV-2 COVID-19 healthcare workers vaccines antibody titer adverse effects |
| title | Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart |
| title_full | Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart |
| title_fullStr | Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart |
| title_full_unstemmed | Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart |
| title_short | Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart |
| title_sort | neutralizing anti sars cov 2 antibody titer and reported adverse effects in a sample of italian nursing home personnel after two doses of the bnt162b2 vaccine administered four weeks apart |
| topic | SARS-CoV-2 COVID-19 healthcare workers vaccines antibody titer adverse effects |
| url | https://www.mdpi.com/2076-393X/9/6/652 |
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