Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications
Objective: To investigate the hemostatic parameters and to assess their relationship with microvascular complications in patients with type-2 diabetes mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-02-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/8260 |
| _version_ | 1797856268801540096 |
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| author | Amna Khan Abdul Rauf Summaya Khan Muhammad Haroon Sarfraz Muhammad Shahid Tarrar Maryam Nisar |
| author_facet | Amna Khan Abdul Rauf Summaya Khan Muhammad Haroon Sarfraz Muhammad Shahid Tarrar Maryam Nisar |
| author_sort | Amna Khan |
| collection | DOAJ |
| description |
Objective: To investigate the hemostatic parameters and to assess their relationship with microvascular complications in patients with type-2 diabetes mellitus.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from Jul to Dec 2020.
Methodology: Patients with type-2 diabetes aged 40-70 years of both genders were included. We included sixty subjects with diabetes and sixty healthy individuals. HBA1c, prothrombin time, activated partial thrombin time, and fibrinogen levels were measured in both groups, and retinal photographs were taken.
Results: The platelet count was in the normal range for both groups but significantly lower in cases compared to controls (177.5±18.3 vs 231.2±18.1, p<0.001). Similarly, the mean fibrinogen level was significantly higher among cases compared to controls (298.2±11.4 vs 256.6±6.5, p<0.001). No significant difference was found between mean prothrombin time and activated partial thromboplastin time among the groups. Most complicated cases belonged to the group with more than 7% glycosylated haemoglobin compared to non-complicated cases (p<0.001). A significant association between the level of HBA1c and diabetic retinopathy was found.
Conclusion: The study showed that with a rise in glycemic index, the coagulation profile derangement occurs, with an increase in fibrinogen levels, decrease in platelets count and increase in microvascular complications.
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| first_indexed | 2024-04-09T20:37:41Z |
| format | Article |
| id | doaj.art-33a522011a6346ae966ad5c96e45b3ff |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-09T20:37:41Z |
| publishDate | 2023-02-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-33a522011a6346ae966ad5c96e45b3ff2023-03-30T06:25:17ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-02-0173110.51253/pafmj.v73i1.8260Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular ComplicationsAmna Khan0Abdul Rauf1Summaya Khan2Muhammad Haroon Sarfraz3Muhammad Shahid Tarrar4Maryam Nisar5Armed Forces Institute of Ophthalmology/National University of Medical Science(NUMS) Rawalpindi PakistanArmed Forces Institute of Ophthalmology/National University of Medical Science(NUMS) Rawalpindi PakistanArmed Forces Institute of Ophthalmology/National University of Medical Science(NUMS) Rawalpindi PakistanArmed Forces Institute of Ophthalmology/National University of Medical Science(NUMS) Rawalpindi PakistanArmed Forces Institute of Ophthalmology/National University of Medical Science(NUMS) Rawalpindi PakistanArmed Forces Institute of Ophthalmology/National University of Medical Science(NUMS) Rawalpindi Pakistan Objective: To investigate the hemostatic parameters and to assess their relationship with microvascular complications in patients with type-2 diabetes mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from Jul to Dec 2020. Methodology: Patients with type-2 diabetes aged 40-70 years of both genders were included. We included sixty subjects with diabetes and sixty healthy individuals. HBA1c, prothrombin time, activated partial thrombin time, and fibrinogen levels were measured in both groups, and retinal photographs were taken. Results: The platelet count was in the normal range for both groups but significantly lower in cases compared to controls (177.5±18.3 vs 231.2±18.1, p<0.001). Similarly, the mean fibrinogen level was significantly higher among cases compared to controls (298.2±11.4 vs 256.6±6.5, p<0.001). No significant difference was found between mean prothrombin time and activated partial thromboplastin time among the groups. Most complicated cases belonged to the group with more than 7% glycosylated haemoglobin compared to non-complicated cases (p<0.001). A significant association between the level of HBA1c and diabetic retinopathy was found. Conclusion: The study showed that with a rise in glycemic index, the coagulation profile derangement occurs, with an increase in fibrinogen levels, decrease in platelets count and increase in microvascular complications. https://www.pafmj.org/index.php/PAFMJ/article/view/8260FibrinogenProthrombinRetinopathy |
| spellingShingle | Amna Khan Abdul Rauf Summaya Khan Muhammad Haroon Sarfraz Muhammad Shahid Tarrar Maryam Nisar Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications Pakistan Armed Forces Medical Journal Fibrinogen Prothrombin Retinopathy |
| title | Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications |
| title_full | Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications |
| title_fullStr | Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications |
| title_full_unstemmed | Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications |
| title_short | Coagulation Profile in Diabetes and Its Association with Diabetic Microvascular Complications |
| title_sort | coagulation profile in diabetes and its association with diabetic microvascular complications |
| topic | Fibrinogen Prothrombin Retinopathy |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/8260 |
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