Research advances of modern and traditional medicine on dry age-related macular degeneration
Age-related macular degeneration(ARMD)is one of the main causes of irreversible visual impairment in the middle-aged and elderly people, which severely impacts the patient's life quality and poses a substantial health economic burden on society. There are two types of late ARMD in clinic: wet A...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2022-05-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2022/5/202205021.pdf |
| _version_ | 1818126894046904320 |
|---|---|
| author | Lu Xing Li-Yi Jia Xiao-Ying Sun Meng Guo Jie Jin Yin-Di Wang Ling Huang Yi-Heng Li Zhong-Jing He Rong Li Hui-Ling Cao |
| author_facet | Lu Xing Li-Yi Jia Xiao-Ying Sun Meng Guo Jie Jin Yin-Di Wang Ling Huang Yi-Heng Li Zhong-Jing He Rong Li Hui-Ling Cao |
| author_sort | Lu Xing |
| collection | DOAJ |
| description | Age-related macular degeneration(ARMD)is one of the main causes of irreversible visual impairment in the middle-aged and elderly people, which severely impacts the patient's life quality and poses a substantial health economic burden on society. There are two types of late ARMD in clinic: wet ARMD and dry ARMD. Anti-vascular endothelial growth factor drugs, as first-line clinical drugs for wet ARMD, achieved remarkable efficacy. For dry ARMD, however, effective therapies are in the air. This review focuses on the potential drugs, biological therapies and traditional Chinese medicines that made significant progresses in clinical trials for dry ARMD, including anti-inflammatory drugs(doxycycline and FHTR2163), anti-oxidants(risuteganib and elamipretide), complement inhibitors(APL-2 and zimura), visual cycle modulators(ALK-001), neuroprotective agents(brimonidine), stem cell transplantation(MA09-hRPE and BMMF), gene therapy(HMR59), and traditional Chinese medicine(saffron, curcumin, quercetin and resveratrol). The new drugs exhibited favorable clinical efficacy and broad application prospects, which would foster hope for improvement and treatment of ARMD. |
| first_indexed | 2024-12-11T07:08:42Z |
| format | Article |
| id | doaj.art-33a5272385b04ef291479aeee9a7eaca |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-11T07:08:42Z |
| publishDate | 2022-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-33a5272385b04ef291479aeee9a7eaca2022-12-22T01:16:25ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-05-0122580380810.3980/j.issn.1672-5123.2022.5.21202205021Research advances of modern and traditional medicine on dry age-related macular degenerationLu Xing0Li-Yi Jia1Xiao-Ying Sun2Meng Guo3Jie Jin4Yin-Di Wang5Ling Huang6Yi-Heng Li7Zhong-Jing He8Rong Li9Hui-Ling Cao10Shaanxi Key Laboratory of Ischemic Cardiovascular Disease;Xi'an Key Laboratory of Basic and Translation of Cardiovascular Diabetic Disease;Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an 710021, Shaanxi Province, ChinaSchool of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, ChinaSchool of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, ChinaSchool of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, ChinaSchool of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, ChinaSchool of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, ChinaSchool of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, ChinaSchool of Life Sciences, Northwest University, Xi'an 710069, Shaanxi Province, ChinaSchool of Life Sciences, Northwest University, Xi'an 710069, Shaanxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, Shaanxi Province, ChinaShaanxi Key Laboratory of Ischemic Cardiovascular Disease;Xi'an Key Laboratory of Basic and Translation of Cardiovascular Diabetic Disease;Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an 710021, Shaanxi Province, China; School of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, Shaanxi Province, China; School of Life Sciences, Northwest University, Xi'an 710069, Shaanxi Province, ChinaAge-related macular degeneration(ARMD)is one of the main causes of irreversible visual impairment in the middle-aged and elderly people, which severely impacts the patient's life quality and poses a substantial health economic burden on society. There are two types of late ARMD in clinic: wet ARMD and dry ARMD. Anti-vascular endothelial growth factor drugs, as first-line clinical drugs for wet ARMD, achieved remarkable efficacy. For dry ARMD, however, effective therapies are in the air. This review focuses on the potential drugs, biological therapies and traditional Chinese medicines that made significant progresses in clinical trials for dry ARMD, including anti-inflammatory drugs(doxycycline and FHTR2163), anti-oxidants(risuteganib and elamipretide), complement inhibitors(APL-2 and zimura), visual cycle modulators(ALK-001), neuroprotective agents(brimonidine), stem cell transplantation(MA09-hRPE and BMMF), gene therapy(HMR59), and traditional Chinese medicine(saffron, curcumin, quercetin and resveratrol). The new drugs exhibited favorable clinical efficacy and broad application prospects, which would foster hope for improvement and treatment of ARMD.http://ies.ijo.cn/cn_publish/2022/5/202205021.pdfage-related macular degenerationdrygeographic atrophydrusennew drugscomplement inhibitorstem cell transplantationtraditional chinese medicine |
| spellingShingle | Lu Xing Li-Yi Jia Xiao-Ying Sun Meng Guo Jie Jin Yin-Di Wang Ling Huang Yi-Heng Li Zhong-Jing He Rong Li Hui-Ling Cao Research advances of modern and traditional medicine on dry age-related macular degeneration Guoji Yanke Zazhi age-related macular degeneration dry geographic atrophy drusen new drugs complement inhibitor stem cell transplantation traditional chinese medicine |
| title | Research advances of modern and traditional medicine on dry age-related macular degeneration |
| title_full | Research advances of modern and traditional medicine on dry age-related macular degeneration |
| title_fullStr | Research advances of modern and traditional medicine on dry age-related macular degeneration |
| title_full_unstemmed | Research advances of modern and traditional medicine on dry age-related macular degeneration |
| title_short | Research advances of modern and traditional medicine on dry age-related macular degeneration |
| title_sort | research advances of modern and traditional medicine on dry age related macular degeneration |
| topic | age-related macular degeneration dry geographic atrophy drusen new drugs complement inhibitor stem cell transplantation traditional chinese medicine |
| url | http://ies.ijo.cn/cn_publish/2022/5/202205021.pdf |
| work_keys_str_mv | AT luxing researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT liyijia researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT xiaoyingsun researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT mengguo researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT jiejin researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT yindiwang researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT linghuang researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT yihengli researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT zhongjinghe researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT rongli researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration AT huilingcao researchadvancesofmodernandtraditionalmedicineondryagerelatedmaculardegeneration |