Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease
Parkinson’s disease (PD) and osteoporosis are degenerative diseases that have shared pathomechanisms. To investigate the associations of skull bone density with nigrostriatal dopaminergic degeneration and longitudinal motor prognosis in female patients with PD. We analyzed the data of 260 drug-naïve...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1053786/full |
| _version_ | 1811180225588887552 |
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| author | Seong Ho Jeong Seong Ho Jeong Namki Hong Hye Sun Lee Sookyeong Han Young-gun Lee Yoonju Lee Yoonju Lee Yumie Rhee Young H. Sohn Phil Hyu Lee Phil Hyu Lee |
| author_facet | Seong Ho Jeong Seong Ho Jeong Namki Hong Hye Sun Lee Sookyeong Han Young-gun Lee Yoonju Lee Yoonju Lee Yumie Rhee Young H. Sohn Phil Hyu Lee Phil Hyu Lee |
| author_sort | Seong Ho Jeong |
| collection | DOAJ |
| description | Parkinson’s disease (PD) and osteoporosis are degenerative diseases that have shared pathomechanisms. To investigate the associations of skull bone density with nigrostriatal dopaminergic degeneration and longitudinal motor prognosis in female patients with PD. We analyzed the data of 260 drug-naïve female PD patients aged ≥50 years old who were followed-up for ≥3 years after their first visit to the clinic with baseline dopamine transporter (DAT) imaging. We measured skull bone density as a surrogate marker for systemic bone loss by calculating the Hounsfield unit (HU) in computed tomography scans. A Cox proportional hazard model was built to compare the rates of levodopa-induced dyskinesia (LID) or wearing-off according to skull HU. Longitudinal changes in levodopa-equivalent dose (LED) during a 3-year follow-up were assessed using a linear mixed model. A lower skull HU was associated with lower baseline DAT availability in striatal subregions; however, this relationship was not significant after adjusting for age, disease duration, body mass index, and white matter hyperintensities. After adjusting for confounding factors, a lower skull HU was significantly associated with an increased risk of LID development (hazard ratio = 1.660 per 1 standard deviation decrease, p = 0.007) and wearing-off (hazard ratio = 1.613, p = 0.016) in younger (<67 years) but not in older patients. Furthermore, a lower skull HU was associated with a steeper increase in LED during follow-up in younger patients only (β = –21.99, p < 0.001). This study suggests that baseline skull bone density would be closely linked to motor prognosis in drug naïve women with PD. |
| first_indexed | 2024-04-11T06:46:41Z |
| format | Article |
| id | doaj.art-33a5c562f08d41a19236a03cd5e4e14f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T06:46:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-33a5c562f08d41a19236a03cd5e4e14f2022-12-22T04:39:19ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10537861053786Low skull bone density is associated with poor motor prognosis in women with Parkinson’s diseaseSeong Ho Jeong0Seong Ho Jeong1Namki Hong2Hye Sun Lee3Sookyeong Han4Young-gun Lee5Yoonju Lee6Yoonju Lee7Yumie Rhee8Young H. Sohn9Phil Hyu Lee10Phil Hyu Lee11Department of Neurology, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, South KoreaBiostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South KoreaEndocrine Research Institute, Severance Hospital, Seoul, South KoreaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Health Promotion, Severance Health Check-Up, Severance Hospital, Yonsei University Health System, Seoul, South KoreaDepartment of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South KoreaSeverance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South KoreaParkinson’s disease (PD) and osteoporosis are degenerative diseases that have shared pathomechanisms. To investigate the associations of skull bone density with nigrostriatal dopaminergic degeneration and longitudinal motor prognosis in female patients with PD. We analyzed the data of 260 drug-naïve female PD patients aged ≥50 years old who were followed-up for ≥3 years after their first visit to the clinic with baseline dopamine transporter (DAT) imaging. We measured skull bone density as a surrogate marker for systemic bone loss by calculating the Hounsfield unit (HU) in computed tomography scans. A Cox proportional hazard model was built to compare the rates of levodopa-induced dyskinesia (LID) or wearing-off according to skull HU. Longitudinal changes in levodopa-equivalent dose (LED) during a 3-year follow-up were assessed using a linear mixed model. A lower skull HU was associated with lower baseline DAT availability in striatal subregions; however, this relationship was not significant after adjusting for age, disease duration, body mass index, and white matter hyperintensities. After adjusting for confounding factors, a lower skull HU was significantly associated with an increased risk of LID development (hazard ratio = 1.660 per 1 standard deviation decrease, p = 0.007) and wearing-off (hazard ratio = 1.613, p = 0.016) in younger (<67 years) but not in older patients. Furthermore, a lower skull HU was associated with a steeper increase in LED during follow-up in younger patients only (β = –21.99, p < 0.001). This study suggests that baseline skull bone density would be closely linked to motor prognosis in drug naïve women with PD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1053786/fullParkinson’s diseaseosteopenia/osteoporosisdopamine transporter (DAT) imagingprognosisskull bone density |
| spellingShingle | Seong Ho Jeong Seong Ho Jeong Namki Hong Hye Sun Lee Sookyeong Han Young-gun Lee Yoonju Lee Yoonju Lee Yumie Rhee Young H. Sohn Phil Hyu Lee Phil Hyu Lee Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease osteopenia/osteoporosis dopamine transporter (DAT) imaging prognosis skull bone density |
| title | Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease |
| title_full | Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease |
| title_fullStr | Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease |
| title_full_unstemmed | Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease |
| title_short | Low skull bone density is associated with poor motor prognosis in women with Parkinson’s disease |
| title_sort | low skull bone density is associated with poor motor prognosis in women with parkinson s disease |
| topic | Parkinson’s disease osteopenia/osteoporosis dopamine transporter (DAT) imaging prognosis skull bone density |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1053786/full |
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