NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma

Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is the first enzyme in the de novo purine nucleotide synthesis pathway and is essential for cell development. However, the effect of PRPS1 on melanoma proliferation and metastasis remains unclear. This study aimed to investigate the regulatory mechan...

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Bibliographic Details
Main Authors: Guohang Xiong, Yu Feng, Xiaojia Yi, Xuedan Zhang, Xiaoyu Li, Lijuan Yang, Zihan Yi, Buqing Sai, Zhe Yang, Qiao Zhang, Yingmin Kuang, Yuechun Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
PRPS1
NRF2
melanoma
proliferation
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.989263/full

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