Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis
Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively hi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/7/3/0843 |
| _version_ | 1797714556361900032 |
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| author | Karrie Mei-Yee Kiang Xiao-Qin Zhang Gilberto Ka-Kit Leung |
| author_facet | Karrie Mei-Yee Kiang Xiao-Qin Zhang Gilberto Ka-Kit Leung |
| author_sort | Karrie Mei-Yee Kiang |
| collection | DOAJ |
| description | Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed. |
| first_indexed | 2024-03-12T07:53:43Z |
| format | Article |
| id | doaj.art-33a80051abcd403990c379ee8d9968da |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:53:43Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-33a80051abcd403990c379ee8d9968da2023-09-02T20:23:40ZengMDPI AGCancers2072-66942015-07-01731406142410.3390/cancers7030843cancers7030843Long Non-Coding RNAs: The Key Players in Glioma PathogenesisKarrie Mei-Yee Kiang0Xiao-Qin Zhang1Gilberto Ka-Kit Leung2Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, ChinaDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, ChinaDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, ChinaLong non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.http://www.mdpi.com/2072-6694/7/3/0843lncRNAgliomaCRNDEHOTAIRH19MEG3glioblastoma stem cellbiomarkergliomagenesis |
| spellingShingle | Karrie Mei-Yee Kiang Xiao-Qin Zhang Gilberto Ka-Kit Leung Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis Cancers lncRNA glioma CRNDE HOTAIR H19 MEG3 glioblastoma stem cell biomarker gliomagenesis |
| title | Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis |
| title_full | Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis |
| title_fullStr | Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis |
| title_full_unstemmed | Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis |
| title_short | Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis |
| title_sort | long non coding rnas the key players in glioma pathogenesis |
| topic | lncRNA glioma CRNDE HOTAIR H19 MEG3 glioblastoma stem cell biomarker gliomagenesis |
| url | http://www.mdpi.com/2072-6694/7/3/0843 |
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