Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation

Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation

Abstract Background Transwell-based models of the blood–brain barrier (BBB) incorporating monolayers of human brain microvascular endothelial cells (dhBMECs) derived from induced pluripotent stem cells show many of the key features of the BBB, including expression of transporters and efflux pumps, e...

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Bibliographic Details
Main Authors: Moriah E. Katt, Raleigh M. Linville, Lakyn N. Mayo, Zinnia S. Xu, Peter C. Searson
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Brain microvascular endothelial cells
Stem cells
Transendothelial electrical resistance
Microvessels
Tissue-engineering
Online Access:http://link.springer.com/article/10.1186/s12987-018-0092-7

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