The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression
Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1 (PDZ) domains, participating in multiple signaling pathways and modulating cellular physiology. It has been identified as an oncogene, promoting cancer development, metastasis, and angiogenesis in various carcinom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9418 |
| _version_ | 1797597383963443200 |
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| author | Kwang-Min Lee Eun-Chan Seo Jeong-Hyung Lee Hyo-Jin Kim Cheol Hwangbo |
| author_facet | Kwang-Min Lee Eun-Chan Seo Jeong-Hyung Lee Hyo-Jin Kim Cheol Hwangbo |
| author_sort | Kwang-Min Lee |
| collection | DOAJ |
| description | Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1 (PDZ) domains, participating in multiple signaling pathways and modulating cellular physiology. It has been identified as an oncogene, promoting cancer development, metastasis, and angiogenesis in various carcinomas. Syntenin-1 is also associated with the production and release of exosomes, small extracellular vesicles that play a significant role in intercellular communication by containing bioactive molecules such as proteins, lipids, and nucleic acids. The trafficking of exosomes involves a complex interplay of various regulatory proteins, including syntenin-1, which interacts with its binding partners, syndecan and activated leukocyte cell adhesion molecule (ALIX). Exosomal transfer of microRNAs, a key cargo, can regulate the expression of various cancer-related genes, including syntenin-1. Targeting the mechanism involving the regulation of exosomes by syntenin-1 and microRNAs may provide a novel treatment strategy for cancer. This review highlights the current understanding of syntenin-1’s role in regulating exosome trafficking and its associated cellular signaling pathways. |
| first_indexed | 2024-03-11T03:05:28Z |
| format | Article |
| id | doaj.art-33aa15a021134ef58bca84bda8759372 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:28Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-33aa15a021134ef58bca84bda87593722023-11-18T07:58:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411941810.3390/ijms24119418The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor ProgressionKwang-Min Lee0Eun-Chan Seo1Jeong-Hyung Lee2Hyo-Jin Kim3Cheol Hwangbo4Division of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of KoreaDivision of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of KoreaDepartment of Biochemistry (BK21 Four), College of Natural Sciences, Kangwon National University, Chuncheon 24414, Republic of KoreaDivision of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of KoreaDivision of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of KoreaSyntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1 (PDZ) domains, participating in multiple signaling pathways and modulating cellular physiology. It has been identified as an oncogene, promoting cancer development, metastasis, and angiogenesis in various carcinomas. Syntenin-1 is also associated with the production and release of exosomes, small extracellular vesicles that play a significant role in intercellular communication by containing bioactive molecules such as proteins, lipids, and nucleic acids. The trafficking of exosomes involves a complex interplay of various regulatory proteins, including syntenin-1, which interacts with its binding partners, syndecan and activated leukocyte cell adhesion molecule (ALIX). Exosomal transfer of microRNAs, a key cargo, can regulate the expression of various cancer-related genes, including syntenin-1. Targeting the mechanism involving the regulation of exosomes by syntenin-1 and microRNAs may provide a novel treatment strategy for cancer. This review highlights the current understanding of syntenin-1’s role in regulating exosome trafficking and its associated cellular signaling pathways.https://www.mdpi.com/1422-0067/24/11/9418syntenin-1exosomemicroRNAtumor microenvironmenttrafficking |
| spellingShingle | Kwang-Min Lee Eun-Chan Seo Jeong-Hyung Lee Hyo-Jin Kim Cheol Hwangbo The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression International Journal of Molecular Sciences syntenin-1 exosome microRNA tumor microenvironment trafficking |
| title | The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression |
| title_full | The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression |
| title_fullStr | The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression |
| title_full_unstemmed | The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression |
| title_short | The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression |
| title_sort | multifunctional protein syntenin 1 regulator of exosome biogenesis cellular function and tumor progression |
| topic | syntenin-1 exosome microRNA tumor microenvironment trafficking |
| url | https://www.mdpi.com/1422-0067/24/11/9418 |
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