Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis
Introduction: Secondary infections are an important cause of morbidity and mortality related to SARS-CoV-2 infection. Early administration of effective antimicrobials improves patient outcome of such infections. In the present study, we investigated secondary blood stream infections (BSI) among COVI...
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| Format: | Article |
| Language: | English |
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Sri Lankan Society for Microbiology
2023-04-01
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| Series: | Sri Lankan Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | https://account.sljid.sljol.info/index.php/sljo-j-sljid/article/view/8524 |
| _version_ | 1797394126116749312 |
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| author | K. D. Namalie W. H. S. De Silva F. S. Makeen G. Premawansa |
| author_facet | K. D. Namalie W. H. S. De Silva F. S. Makeen G. Premawansa |
| author_sort | K. D. Namalie |
| collection | DOAJ |
| description | Introduction: Secondary infections are an important cause of morbidity and mortality related to SARS-CoV-2 infection. Early administration of effective antimicrobials improves patient outcome of such infections. In the present study, we investigated secondary blood stream infections (BSI) among COVID-19 patients in Colombo North Teaching Hospital, Sri Lanka (CNTH).
Methods: This is a descriptive study, performed to analyse blood culture positive events retrospectively in patients hospitalized with COVID-19 in our institution from 1st June 2021 to 30th November 2021.
Results: Of a total 434 blood cultures received from SARS-COV-2 positive patients, the overall blood culture positivity rate was 25.3 % (110/434) of which 11.7% (51/434) were clinically relevant bacteraemias. The contamination rate was 13.7% (59/434). Of the 60 isolates from clinically relevant bacteraemias, 60% (36/60) were Gram negative organisms, 31.7% (19/60) were Gram positive organisms and 8.3% (5/60) were Candida spp. The most prevalent isolates were Enterococcus spp. (20%; 12/60) and Acinetobacter spp. (15%; 9/60).
Higher rates of multi drug resistance were observed among Gram negative isolates. The proportion of 3rd generation cephalosporins and ciprofloxacin resistance among enterobacterales was 81.3% and carbapenem resistance among Acinetobacter spp. was 77.8%. A primary focus of infection could be identified in only 18 blood stream infections (BSI).
Conclusion: A high rate of significant BSIs was detected in this patient cohort. Blood culture contamination rate among COVID-19 patients was higher than the usual rates in the institution. A high number of bacteraemias due to Enterococcus spp. and Acinetobacter spp. were noted and overall antibiotic resistance among Gram negative organisms was high. |
| first_indexed | 2024-03-09T00:14:56Z |
| format | Article |
| id | doaj.art-33aa6a8ef17b4e4da80c7eb619712254 |
| institution | Directory Open Access Journal |
| issn | 2012-8169 2448-9654 |
| language | English |
| last_indexed | 2024-03-09T00:14:56Z |
| publishDate | 2023-04-01 |
| publisher | Sri Lankan Society for Microbiology |
| record_format | Article |
| series | Sri Lankan Journal of Infectious Diseases |
| spelling | doaj.art-33aa6a8ef17b4e4da80c7eb6197122542023-12-12T08:10:58ZengSri Lankan Society for MicrobiologySri Lankan Journal of Infectious Diseases2012-81692448-96542023-04-01131E37 11010.4038/sljid.v13i1.8524485Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysisK. D. Namalie0https://orcid.org/0000-0003-4970-1169W. H. S. De Silva1https://orcid.org/0000-0002-3442-3330F. S. Makeen2https://orcid.org/0000-0002-2971-8097G. Premawansa3https://orcid.org/0000-0002-8271-2436Colombo North Teaching Hospital, RagamaColombo North Teaching Hospital, RagamaColombo North Teaching Hospital, RagamaColombo North Teaching Hospital, RagamaIntroduction: Secondary infections are an important cause of morbidity and mortality related to SARS-CoV-2 infection. Early administration of effective antimicrobials improves patient outcome of such infections. In the present study, we investigated secondary blood stream infections (BSI) among COVID-19 patients in Colombo North Teaching Hospital, Sri Lanka (CNTH). Methods: This is a descriptive study, performed to analyse blood culture positive events retrospectively in patients hospitalized with COVID-19 in our institution from 1st June 2021 to 30th November 2021. Results: Of a total 434 blood cultures received from SARS-COV-2 positive patients, the overall blood culture positivity rate was 25.3 % (110/434) of which 11.7% (51/434) were clinically relevant bacteraemias. The contamination rate was 13.7% (59/434). Of the 60 isolates from clinically relevant bacteraemias, 60% (36/60) were Gram negative organisms, 31.7% (19/60) were Gram positive organisms and 8.3% (5/60) were Candida spp. The most prevalent isolates were Enterococcus spp. (20%; 12/60) and Acinetobacter spp. (15%; 9/60). Higher rates of multi drug resistance were observed among Gram negative isolates. The proportion of 3rd generation cephalosporins and ciprofloxacin resistance among enterobacterales was 81.3% and carbapenem resistance among Acinetobacter spp. was 77.8%. A primary focus of infection could be identified in only 18 blood stream infections (BSI). Conclusion: A high rate of significant BSIs was detected in this patient cohort. Blood culture contamination rate among COVID-19 patients was higher than the usual rates in the institution. A high number of bacteraemias due to Enterococcus spp. and Acinetobacter spp. were noted and overall antibiotic resistance among Gram negative organisms was high.https://account.sljid.sljol.info/index.php/sljo-j-sljid/article/view/8524sars-cov-2 viruscovid-19secondary blood stream infectionsantimicrobial resistance |
| spellingShingle | K. D. Namalie W. H. S. De Silva F. S. Makeen G. Premawansa Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis Sri Lankan Journal of Infectious Diseases sars-cov-2 virus covid-19 secondary blood stream infections antimicrobial resistance |
| title | Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis |
| title_full | Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis |
| title_fullStr | Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis |
| title_full_unstemmed | Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis |
| title_short | Prevalence of secondary blood stream infections in patients with SARS- CoV-2 infection in a tertiary care hospital in Sri Lanka: A retrospective analysis |
| title_sort | prevalence of secondary blood stream infections in patients with sars cov 2 infection in a tertiary care hospital in sri lanka a retrospective analysis |
| topic | sars-cov-2 virus covid-19 secondary blood stream infections antimicrobial resistance |
| url | https://account.sljid.sljol.info/index.php/sljo-j-sljid/article/view/8524 |
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