ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature
Abstract Systemic sclerosis (SSc) is a multi‐system autoimmune disease. Anti‐neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12153 |
| _version_ | 1797335046579814400 |
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| author | Kayo Takenaka Takuya Takeichi Ryoji Nishi Masashi Suzuki Haruki Koike Masahisa Katsuno Mariko Ogawa‐Momohara Yoshinao Muro Masashi Akiyama |
| author_facet | Kayo Takenaka Takuya Takeichi Ryoji Nishi Masashi Suzuki Haruki Koike Masahisa Katsuno Mariko Ogawa‐Momohara Yoshinao Muro Masashi Akiyama |
| author_sort | Kayo Takenaka |
| collection | DOAJ |
| description | Abstract Systemic sclerosis (SSc) is a multi‐system autoimmune disease. Anti‐neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA‐associated vasculitis. We summarize previous reports on SSc patients with ANCA‐associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA‐associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA‐associated neuropathy in lSSc may be prone to complication with ILD. |
| first_indexed | 2024-03-08T08:31:11Z |
| format | Article |
| id | doaj.art-33aaf62404b8437fbb91675f628deddf |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T08:31:11Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-33aaf62404b8437fbb91675f628deddf2024-02-02T03:00:33ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932021-04-0142343610.1002/cia2.12153ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literatureKayo Takenaka0Takuya Takeichi1Ryoji Nishi2Masashi Suzuki3Haruki Koike4Masahisa Katsuno5Mariko Ogawa‐Momohara6Yoshinao Muro7Masashi Akiyama8Department of Dermatology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Dermatology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Neurology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Neurology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Neurology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Neurology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Dermatology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Dermatology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Dermatology Nagoya University Graduate School of Medicine Nagoya JapanAbstract Systemic sclerosis (SSc) is a multi‐system autoimmune disease. Anti‐neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA‐associated vasculitis. We summarize previous reports on SSc patients with ANCA‐associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA‐associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA‐associated neuropathy in lSSc may be prone to complication with ILD.https://doi.org/10.1002/cia2.12153ANCA‐associated neuropathyanti‐neutrophil cytoplasmic antibodyinterstitial lung diseasesystemic sclerosis |
| spellingShingle | Kayo Takenaka Takuya Takeichi Ryoji Nishi Masashi Suzuki Haruki Koike Masahisa Katsuno Mariko Ogawa‐Momohara Yoshinao Muro Masashi Akiyama ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature Journal of Cutaneous Immunology and Allergy ANCA‐associated neuropathy anti‐neutrophil cytoplasmic antibody interstitial lung disease systemic sclerosis |
| title | ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature |
| title_full | ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature |
| title_fullStr | ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature |
| title_full_unstemmed | ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature |
| title_short | ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature |
| title_sort | anca associated neuropathy in systemic sclerosis a case report and review of literature |
| topic | ANCA‐associated neuropathy anti‐neutrophil cytoplasmic antibody interstitial lung disease systemic sclerosis |
| url | https://doi.org/10.1002/cia2.12153 |
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