DUX4 Role in Normal Physiology and in FSHD Muscular Dystrophy
In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4) has gone from being an obscure entity to being a key factor in important physiological and pathological processes. We now know that expression of DUX4 is highly regulated and restricted to the early steps of embr...
Main Authors: | Emanuele Mocciaro, Valeria Runfola, Paola Ghezzi, Maria Pannese, Davide Gabellini |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-11-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/10/12/3322 |
Similar Items
-
Culture Conditions Affect Expression of DUX4 in FSHD Myoblasts
by: Sachchida Nand Pandey, et al.
Published: (2015-05-01) -
Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular Dystrophy
by: Massimo Ganassi, et al.
Published: (2022-09-01) -
A dedicated caller for DUX4 rearrangements from whole-genome sequencing data
by: Pascal Grobecker, et al.
Published: (2025-01-01) -
Long-Term Systemic Treatment of a Mouse Model Displaying Chronic FSHD-like Pathology with Antisense Therapeutics That Inhibit <i>DUX4</i> Expression
by: Ngoc Lu-Nguyen, et al.
Published: (2022-07-01) -
Identification of candidate miRNA biomarkers for facioscapulohumeral muscular dystrophy using DUX4-based mouse models
by: Andreia M. Nunes, et al.
Published: (2021-08-01)