Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea
BackgroundObstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with nor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1361466/full |
| _version_ | 1797279245526892544 |
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| author | MengShi Tao MengShi Tao Xiaoqi Dong Jinjing Tu Qing Fang Chuan Shao Chuan Shao |
| author_facet | MengShi Tao MengShi Tao Xiaoqi Dong Jinjing Tu Qing Fang Chuan Shao Chuan Shao |
| author_sort | MengShi Tao |
| collection | DOAJ |
| description | BackgroundObstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with normal blood pressure have not been fully defined.MethodsThis study retrospectively analyzed OSA patients diagnosed for the first time in Lihuili Hospital Affiliated to Ningbo University from 2016 to 2020. Patients were divided into an OSA group with hypertension and an OSA group without hypertension. The sociodemographic information, clinical symptoms, comorbidities, and polysomnography results of the two groups were compared. The independent risk factors associated with hypertension in patients with OSA were explored.ResultsA total of 1108 patients with OSA initially diagnosed were included in the study, including 387 with hypertension and 721 without. Compared with OSA patients without hypertension, OSA patients with hypertension were older; had a higher body mass index (BMI) and Epworth sleepiness score (ESS); a higher incidence of nocturia; and a higher proportion of diabetes mellitus, coronary heart disease, and cerebrovascular disease. Multivariate analysis showed age (odds ratio [OR]:1.06, 95% confidence interval [CI]:1.04-1.08), BMI (OR:1.17, 95% CI:1.11-1.23), ESS score (OR:0.97, 95%CI: 0.94-1.00) and nocturia symptoms (OR:1.64, 95% CI:1.19-2.27) was independently associated with hypertension in OSA patients, and comorbid diabetes (OR: 3.86, 95% CI: 2.31-6.45), coronary heart disease (OR: 1.90, 95% CI:1.15-3.16), and ischemic stroke (OR: 3.69,95% CI:1.31-10.40) was independently associated with hypertension in OSA patients.ConclusionCompared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease. |
| first_indexed | 2024-03-07T16:21:31Z |
| format | Article |
| id | doaj.art-33ad65fd57a745ebb6c25f8b23fbe792 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T16:21:31Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-33ad65fd57a745ebb6c25f8b23fbe7922024-03-04T04:51:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13614661361466Symptom and comorbidity burden in hypertensive patients with obstructive sleep apneaMengShi Tao0MengShi Tao1Xiaoqi Dong2Jinjing Tu3Qing Fang4Chuan Shao5Chuan Shao6Department of Respiratory and Critical Care Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaBackgroundObstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with normal blood pressure have not been fully defined.MethodsThis study retrospectively analyzed OSA patients diagnosed for the first time in Lihuili Hospital Affiliated to Ningbo University from 2016 to 2020. Patients were divided into an OSA group with hypertension and an OSA group without hypertension. The sociodemographic information, clinical symptoms, comorbidities, and polysomnography results of the two groups were compared. The independent risk factors associated with hypertension in patients with OSA were explored.ResultsA total of 1108 patients with OSA initially diagnosed were included in the study, including 387 with hypertension and 721 without. Compared with OSA patients without hypertension, OSA patients with hypertension were older; had a higher body mass index (BMI) and Epworth sleepiness score (ESS); a higher incidence of nocturia; and a higher proportion of diabetes mellitus, coronary heart disease, and cerebrovascular disease. Multivariate analysis showed age (odds ratio [OR]:1.06, 95% confidence interval [CI]:1.04-1.08), BMI (OR:1.17, 95% CI:1.11-1.23), ESS score (OR:0.97, 95%CI: 0.94-1.00) and nocturia symptoms (OR:1.64, 95% CI:1.19-2.27) was independently associated with hypertension in OSA patients, and comorbid diabetes (OR: 3.86, 95% CI: 2.31-6.45), coronary heart disease (OR: 1.90, 95% CI:1.15-3.16), and ischemic stroke (OR: 3.69,95% CI:1.31-10.40) was independently associated with hypertension in OSA patients.ConclusionCompared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease.https://www.frontiersin.org/articles/10.3389/fendo.2024.1361466/fullobstructive sleep apneahypertensiondaytime sleepinessnocturiacomorbidity |
| spellingShingle | MengShi Tao MengShi Tao Xiaoqi Dong Jinjing Tu Qing Fang Chuan Shao Chuan Shao Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea Frontiers in Endocrinology obstructive sleep apnea hypertension daytime sleepiness nocturia comorbidity |
| title | Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea |
| title_full | Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea |
| title_fullStr | Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea |
| title_full_unstemmed | Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea |
| title_short | Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea |
| title_sort | symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea |
| topic | obstructive sleep apnea hypertension daytime sleepiness nocturia comorbidity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1361466/full |
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