Fragment screening for a protein-protein interaction inhibitor to WDR5

Fragment screening for a protein-protein interaction inhibitor to WDR5

The WD40-repeat protein WDR5 scaffolds various epigenetic writers and is a critical component of the mammalian SET/MLL histone methyltransferase complex. Dysregulation of the MLL1 catalytic function is associated with mixed-lineage leukemia, and antagonism of the WDR5-MLL1 interaction by small molec...

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Bibliographic Details
Main Authors: Matthew L. Dennis, Benjamin J. Morrow, Olan Dolezal, Anthony N. Cuzzupe, Alexandra E. Stupple, Janet Newman, John Bentley, Meghan Hattarki, Stewart D. Nuttall, Richard C. Foitzik, Ian P. Street, Paul A. Stupple, Brendon J. Monahan, Thomas. S. Peat
Format: Article
Language:English
Published: AIP Publishing LLC and ACA 2019-11-01
Series:Structural Dynamics
Online Access:http://dx.doi.org/10.1063/1.5122849

Internet

http://dx.doi.org/10.1063/1.5122849

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