Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma

Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma

Background Immune-related adverse events (irAEs) are major barriers of clinical management and further development of immune checkpoint inhibitors (ICIs) for cancer therapy. Therefore, biomarkers associated with the onset of severe irAEs are needed. In this study, we aimed to identify immune feature...

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Bibliographic Details
Main Authors: Siwen Hu-Lieskovan, Ngan Nguyen, Magdalena Kovacsovics-Bankowski, John Hyngstrom, Li-Chun Cheng, Jordan P McPherson, Umang Swami, Matthew H Spitzer, Johanna M Sweere, Connor P Healy, Natalia Sigal, William D Chronister, Shane A Evans, John Marsiglio, Berit Gibson, Alyssa Erickson-Wayman, Yoko S Derose, Annaleah Larson Eliason, Carlos O Medina, Ramji Srinivasan
Format: Article
Language:English
Published: BMJ Publishing Group 2024-01-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/1/e008056.full

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