Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging

Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging

This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their ph...

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Bibliographic Details
Main Authors: Przemysław Koźmiński, Weronika Gawęda, Magdalena Rzewuska, Agata Kopatys, Szymon Kujda, Marta K. Dudek, Paweł Krzysztof Halik, Leszek Królicki, Ewa Gniazdowska
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Tomography
Subjects:
ciprofloxacin
technetium-99m
gallium-68
radiopharmaceutical
bacterial infection
diabetic foot
Online Access:https://www.mdpi.com/2379-139X/7/4/70
Description
Summary:This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT.
ISSN:2379-1381
2379-139X

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