Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging
This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their ph...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/7/4/70 |
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| author | Przemysław Koźmiński Weronika Gawęda Magdalena Rzewuska Agata Kopatys Szymon Kujda Marta K. Dudek Paweł Krzysztof Halik Leszek Królicki Ewa Gniazdowska |
| author_facet | Przemysław Koźmiński Weronika Gawęda Magdalena Rzewuska Agata Kopatys Szymon Kujda Marta K. Dudek Paweł Krzysztof Halik Leszek Królicki Ewa Gniazdowska |
| author_sort | Przemysław Koźmiński |
| collection | DOAJ |
| description | This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT. |
| first_indexed | 2024-03-10T03:58:46Z |
| format | Article |
| id | doaj.art-33aef70d2cc44a0ea5cbe0ad98b576c7 |
| institution | Directory Open Access Journal |
| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-10T03:58:46Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tomography |
| spelling | doaj.art-33aef70d2cc44a0ea5cbe0ad98b576c72023-11-23T10:49:18ZengMDPI AGTomography2379-13812379-139X2021-12-017482984210.3390/tomography7040070Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome ImagingPrzemysław Koźmiński0Weronika Gawęda1Magdalena Rzewuska2Agata Kopatys3Szymon Kujda4Marta K. Dudek5Paweł Krzysztof Halik6Leszek Królicki7Ewa Gniazdowska8Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, PolandCentre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, PolandInstitute of Veterinary Medicine, Department of Preclinical Sciences, Division of Microbiology, Warsaw University of Life Sciences—SGGW, Ciszewskiego 8, 02-786 Warsaw, PolandDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, PolandDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, PolandCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, PolandCentre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, PolandDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, PolandCentre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, PolandThis paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT.https://www.mdpi.com/2379-139X/7/4/70ciprofloxacintechnetium-99mgallium-68radiopharmaceuticalbacterial infectiondiabetic foot |
| spellingShingle | Przemysław Koźmiński Weronika Gawęda Magdalena Rzewuska Agata Kopatys Szymon Kujda Marta K. Dudek Paweł Krzysztof Halik Leszek Królicki Ewa Gniazdowska Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging Tomography ciprofloxacin technetium-99m gallium-68 radiopharmaceutical bacterial infection diabetic foot |
| title | Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging |
| title_full | Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging |
| title_fullStr | Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging |
| title_full_unstemmed | Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging |
| title_short | Physicochemical and Biological Study of <sup>99m</sup>Tc and <sup>68</sup>Ga Radiolabelled Ciprofloxacin and Evaluation of [<sup>99m</sup>Tc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging |
| title_sort | physicochemical and biological study of sup 99m sup tc and sup 68 sup ga radiolabelled ciprofloxacin and evaluation of sup 99m sup tc tc cip as potential diagnostic radiopharmaceutical for diabetic foot syndrome imaging |
| topic | ciprofloxacin technetium-99m gallium-68 radiopharmaceutical bacterial infection diabetic foot |
| url | https://www.mdpi.com/2379-139X/7/4/70 |
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