STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON
Introduction. Nootropic drugs are components of complex therapy for various neurological dysfunctions. One of the classes of ND are pyrrolidone derivatives, which, in addition to a direct effect on cognitive functions, increase the brain's resistance to hypoxia.Aim. The work was to study the ef...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-02-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/652 |
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| author | T. A. Sapozhnikova N. S. Makara S. F. Gabdrakhmanova R. Yu. Khisamutdinova |
| author_facet | T. A. Sapozhnikova N. S. Makara S. F. Gabdrakhmanova R. Yu. Khisamutdinova |
| author_sort | T. A. Sapozhnikova |
| collection | DOAJ |
| description | Introduction. Nootropic drugs are components of complex therapy for various neurological dysfunctions. One of the classes of ND are pyrrolidone derivatives, which, in addition to a direct effect on cognitive functions, increase the brain's resistance to hypoxia.Aim. The work was to study the effect of the 3-aminopyrrolidin-2-one derivative containing the norbornane fragment (P-11) on different memory phases in rats and to evaluate its antihypoxic properties.Materials and methods. The effect of P-11 on memory was assessed on passive avoidance test (PAT) in rats. The antihypoxic properties of P-11 were studied on a model of acute normobaric hypoxia with hypercapnia, assessing the life span of laboratory animals and the level of lipid peroxidation processes in the brain.Results and discussion. It was shown that the introduction of P-11 at different stages of the development of passive avoidance reaction improves the ability of animals to learn and extract a memorable trace of pain stimulation 24 hours after the development of a reflex. On a model of normobaric hypoxia with a single injection, P-11 showed a tendency to increase the life span of rats relative to the control, and with a 14-day treatment, pronounced antihypoxic properties were observed compared with other pyrrolidone derivatives, pyracetam and phenotropil, which manifested in an increase in life span of mice, as well as in lowering lipid peroxidation processes in brain tissue.Conclusion. Thus, it was shown that a new derivative 3-aminopyrrolidin-2-it exhibits nootropic and antihypoxic properties. |
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| format | Article |
| id | doaj.art-33afa7e8a5fb406ea9218065ebf0fdf5 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2025-03-14T11:44:02Z |
| publishDate | 2019-02-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-33afa7e8a5fb406ea9218065ebf0fdf52025-03-02T09:53:22ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-02-0181869010.33380/2305-2066-2019-8-1-86-90652STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ONT. A. Sapozhnikova0N. S. Makara1S. F. Gabdrakhmanova2R. Yu. Khisamutdinova3Ufa Institute of of the Chemistry – Subdivision Ufa Federal Research Centre RASUfa Institute of of the Chemistry – Subdivision Ufa Federal Research Centre RASUfa Institute of of the Chemistry – Subdivision Ufa Federal Research Centre RASUfa Institute of of the Chemistry – Subdivision Ufa Federal Research Centre RASIntroduction. Nootropic drugs are components of complex therapy for various neurological dysfunctions. One of the classes of ND are pyrrolidone derivatives, which, in addition to a direct effect on cognitive functions, increase the brain's resistance to hypoxia.Aim. The work was to study the effect of the 3-aminopyrrolidin-2-one derivative containing the norbornane fragment (P-11) on different memory phases in rats and to evaluate its antihypoxic properties.Materials and methods. The effect of P-11 on memory was assessed on passive avoidance test (PAT) in rats. The antihypoxic properties of P-11 were studied on a model of acute normobaric hypoxia with hypercapnia, assessing the life span of laboratory animals and the level of lipid peroxidation processes in the brain.Results and discussion. It was shown that the introduction of P-11 at different stages of the development of passive avoidance reaction improves the ability of animals to learn and extract a memorable trace of pain stimulation 24 hours after the development of a reflex. On a model of normobaric hypoxia with a single injection, P-11 showed a tendency to increase the life span of rats relative to the control, and with a 14-day treatment, pronounced antihypoxic properties were observed compared with other pyrrolidone derivatives, pyracetam and phenotropil, which manifested in an increase in life span of mice, as well as in lowering lipid peroxidation processes in brain tissue.Conclusion. Thus, it was shown that a new derivative 3-aminopyrrolidin-2-it exhibits nootropic and antihypoxic properties.https://www.pharmjournal.ru/jour/article/view/6525-amino-3-exo-azatricyclo[5.2.1.0<sup>2,6</sup>]decan-4-onactivitynootropic activitypassive avoidance taskantihypoxic activitynormobaric hypoxia |
| spellingShingle | T. A. Sapozhnikova N. S. Makara S. F. Gabdrakhmanova R. Yu. Khisamutdinova STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON Разработка и регистрация лекарственных средств 5-amino-3-exo-azatricyclo[5.2.1.0<sup>2,6</sup>]decan-4-on activity nootropic activity passive avoidance task antihypoxic activity normobaric hypoxia |
| title | STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON |
| title_full | STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON |
| title_fullStr | STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON |
| title_full_unstemmed | STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON |
| title_short | STUDY OF NOOTROPIC AND ANTI-HYPOXIC ACTIVITY OF 5-AMINO-3-EXO-AZATRICYCLO[5.2.1.0<sup>2,6</sup>]DECAN-4-ON |
| title_sort | study of nootropic and anti hypoxic activity of 5 amino 3 exo azatricyclo 5 2 1 0 sup 2 6 sup decan 4 on |
| topic | 5-amino-3-exo-azatricyclo[5.2.1.0<sup>2,6</sup>]decan-4-on activity nootropic activity passive avoidance task antihypoxic activity normobaric hypoxia |
| url | https://www.pharmjournal.ru/jour/article/view/652 |
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