AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord

AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord

AAV vectors are being used extensively for gene-modifying therapies for neurological disorders. Here, we report the surprising discovery that injections of different AAVs into the brain, spinal cord, or cerebrospinal fluid (CSF) lead to robust transduction of cells in the pineal gland. We document t...

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Bibliographic Details
Main Authors: Oswald Steward, Aminata P. Coulibaly, Mariajose Metcalfe, Jamie M. Dam, Kelly M. Yee
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
AAV vector
pineal gland
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001546

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