Variations in Local Calcium Signaling in Adjacent Cardiac Myocytes of the Intact Mouse Heart Detected with Two-Dimensional Confocal Microscopy

Variations in Local Calcium Signaling in Adjacent Cardiac Myocytes of the Intact Mouse Heart Detected with Two-Dimensional Confocal Microscopy

Dyssynchronous local Ca release within individual cardiac myocytes has been linked to cellular contractile dysfunction. Differences in Ca kinetics in adjacent cells may also provide a substrate for inefficient contraction and arrhythmias. In a new approach we quantify variation in local Ca transient...

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Bibliographic Details
Main Authors: Karin P Hammer, Felix eHohendanner, Lothar A Blatter, Burkert M Pieske, Frank R. Heinzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Physiology
Subjects:
Excitation Contraction Coupling
cardiac myocytes
intercellular communication
calcium cycling
Langendorff perfused heart
Whole Heart
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00517/full

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