Trends in Photothermal Nanostructures for Antimicrobial Applications
The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to addr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9375 |
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| author | Violeta Dediu Jana Ghitman Gratiela Gradisteanu Pircalabioru Kiat Hwa Chan Florina Silvia Iliescu Ciprian Iliescu |
| author_facet | Violeta Dediu Jana Ghitman Gratiela Gradisteanu Pircalabioru Kiat Hwa Chan Florina Silvia Iliescu Ciprian Iliescu |
| author_sort | Violeta Dediu |
| collection | DOAJ |
| description | The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to address drug-resistant bacterial infections in specific, focused, and biologically safe ways. The unique physicochemical properties, biocompatibility, and wide range of adaptability of nanomaterials that exhibit photothermal capability can be employed to develop the next generation of photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review the current state of the art in different functional classes of photothermal antibacterial nanomaterials and strategies to optimise antimicrobial efficiency. The recent achievements and trends in developing photothermally active nanostructures, including plasmonic metals, semiconductors, and carbon-based and organic photothermal polymers, and antibacterial mechanisms of action, including anti-multidrug-resistant bacteria and biofilm removal, will be discussed. Insights into the mechanisms of the photothermal effect and various factors influencing photothermal antimicrobial performance, emphasising the structure–performance relationship, are discussed. We will examine the photothermal agents’ functionalisation for specific bacteria, the effects of the near-infrared light irradiation spectrum, and active photothermal materials for multimodal synergistic-based therapies to minimise side effects and maintain low costs. The most relevant applications are presented, such as antibiofilm formation, biofilm penetration or ablation, and nanomaterial-based infected wound therapy. Practical antibacterial applications employing photothermal antimicrobial agents, alone or in synergistic combination with other nanomaterials, are considered. Existing challenges and limitations in photothermal antimicrobial therapy and future perspectives are presented from the structural, functional, safety, and clinical potential points of view. |
| first_indexed | 2024-03-11T03:05:28Z |
| format | Article |
| id | doaj.art-33b5cd9b70554a0082efb77a9fcad302 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:28Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-33b5cd9b70554a0082efb77a9fcad3022023-11-18T07:58:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411937510.3390/ijms24119375Trends in Photothermal Nanostructures for Antimicrobial ApplicationsVioleta Dediu0Jana Ghitman1Gratiela Gradisteanu Pircalabioru2Kiat Hwa Chan3Florina Silvia Iliescu4Ciprian Iliescu5National Research and Development Institute in Microtechnologies—IMT Bucharest, 126A Erou Iancu Nicolae Street, 077190 Voluntari, RomaniaeBio-hub Research-Center, University “Politehnica” of Bucharest, 6 Iuliu Maniu Boulevard, Campus Building, 061344 Bucharest, RomaniaeBio-hub Research-Center, University “Politehnica” of Bucharest, 6 Iuliu Maniu Boulevard, Campus Building, 061344 Bucharest, RomaniaDivision of Science, Yale-NUS College, 16 College Avenue West, Singapore 138527, SingaporeNational Research and Development Institute in Microtechnologies—IMT Bucharest, 126A Erou Iancu Nicolae Street, 077190 Voluntari, RomaniaNational Research and Development Institute in Microtechnologies—IMT Bucharest, 126A Erou Iancu Nicolae Street, 077190 Voluntari, RomaniaThe rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to address drug-resistant bacterial infections in specific, focused, and biologically safe ways. The unique physicochemical properties, biocompatibility, and wide range of adaptability of nanomaterials that exhibit photothermal capability can be employed to develop the next generation of photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review the current state of the art in different functional classes of photothermal antibacterial nanomaterials and strategies to optimise antimicrobial efficiency. The recent achievements and trends in developing photothermally active nanostructures, including plasmonic metals, semiconductors, and carbon-based and organic photothermal polymers, and antibacterial mechanisms of action, including anti-multidrug-resistant bacteria and biofilm removal, will be discussed. Insights into the mechanisms of the photothermal effect and various factors influencing photothermal antimicrobial performance, emphasising the structure–performance relationship, are discussed. We will examine the photothermal agents’ functionalisation for specific bacteria, the effects of the near-infrared light irradiation spectrum, and active photothermal materials for multimodal synergistic-based therapies to minimise side effects and maintain low costs. The most relevant applications are presented, such as antibiofilm formation, biofilm penetration or ablation, and nanomaterial-based infected wound therapy. Practical antibacterial applications employing photothermal antimicrobial agents, alone or in synergistic combination with other nanomaterials, are considered. Existing challenges and limitations in photothermal antimicrobial therapy and future perspectives are presented from the structural, functional, safety, and clinical potential points of view.https://www.mdpi.com/1422-0067/24/11/9375photothermal antimicrobialsantibacterial mechanismsantibiofilmwound healing |
| spellingShingle | Violeta Dediu Jana Ghitman Gratiela Gradisteanu Pircalabioru Kiat Hwa Chan Florina Silvia Iliescu Ciprian Iliescu Trends in Photothermal Nanostructures for Antimicrobial Applications International Journal of Molecular Sciences photothermal antimicrobials antibacterial mechanisms antibiofilm wound healing |
| title | Trends in Photothermal Nanostructures for Antimicrobial Applications |
| title_full | Trends in Photothermal Nanostructures for Antimicrobial Applications |
| title_fullStr | Trends in Photothermal Nanostructures for Antimicrobial Applications |
| title_full_unstemmed | Trends in Photothermal Nanostructures for Antimicrobial Applications |
| title_short | Trends in Photothermal Nanostructures for Antimicrobial Applications |
| title_sort | trends in photothermal nanostructures for antimicrobial applications |
| topic | photothermal antimicrobials antibacterial mechanisms antibiofilm wound healing |
| url | https://www.mdpi.com/1422-0067/24/11/9375 |
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