Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds
Chronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is distinguished by severe fibrosis caused by the activation of pancreatic stellate cells (PSCs). The current clinical therapeutic protocol for...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1042651/full |
| _version_ | 1811341228790251520 |
|---|---|
| author | Yang Wu Chun Zhang Mei Guo Weikang Hu Yangling Qiu Mengran Li Dong Xu Pengfei Wu Jing Sun Run Shi Zili Zhang Kuirong Jiang |
| author_facet | Yang Wu Chun Zhang Mei Guo Weikang Hu Yangling Qiu Mengran Li Dong Xu Pengfei Wu Jing Sun Run Shi Zili Zhang Kuirong Jiang |
| author_sort | Yang Wu |
| collection | DOAJ |
| description | Chronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is distinguished by severe fibrosis caused by the activation of pancreatic stellate cells (PSCs). The current clinical therapeutic protocol for CP lacks specific therapeutic medicines for the prevention and suppression of inflammation and fibrosis aggravating in CP. More research on specifically targeting PSCs would help facilitate the development of novel therapies for pancreatic fibrosis. Notably, using natural compounds from medicinal plants as new antifibrotic agents has become a focus of recent research and is widely employed as an alternative and complementary approach. Our goal was to shed light on the role of PSCs in the development of CP and provide a focused update on the new potential therapeutic strategies against PSCs in CP models. Future studies can refer to these possible strategies for drug design, bioavailability, pharmacokinetics, and other issues to obtain better clinical outcomes for treating CP. |
| first_indexed | 2024-04-13T18:54:24Z |
| format | Article |
| id | doaj.art-33b71fffc40f4d71b9c8af4f49823f3e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T18:54:24Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-33b71fffc40f4d71b9c8af4f49823f3e2022-12-22T02:34:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10426511042651Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compoundsYang Wu0Chun Zhang1Mei Guo2Weikang Hu3Yangling Qiu4Mengran Li5Dong Xu6Pengfei Wu7Jing Sun8Run Shi9Zili Zhang10Kuirong Jiang11Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaGastroenterology Department, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaJiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaChronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is distinguished by severe fibrosis caused by the activation of pancreatic stellate cells (PSCs). The current clinical therapeutic protocol for CP lacks specific therapeutic medicines for the prevention and suppression of inflammation and fibrosis aggravating in CP. More research on specifically targeting PSCs would help facilitate the development of novel therapies for pancreatic fibrosis. Notably, using natural compounds from medicinal plants as new antifibrotic agents has become a focus of recent research and is widely employed as an alternative and complementary approach. Our goal was to shed light on the role of PSCs in the development of CP and provide a focused update on the new potential therapeutic strategies against PSCs in CP models. Future studies can refer to these possible strategies for drug design, bioavailability, pharmacokinetics, and other issues to obtain better clinical outcomes for treating CP.https://www.frontiersin.org/articles/10.3389/fphar.2022.1042651/fullCPPSCsnatural compoundspancreatic fibrosisanti-fibrotic drug |
| spellingShingle | Yang Wu Chun Zhang Mei Guo Weikang Hu Yangling Qiu Mengran Li Dong Xu Pengfei Wu Jing Sun Run Shi Zili Zhang Kuirong Jiang Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds Frontiers in Pharmacology CP PSCs natural compounds pancreatic fibrosis anti-fibrotic drug |
| title | Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds |
| title_full | Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds |
| title_fullStr | Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds |
| title_full_unstemmed | Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds |
| title_short | Targeting pancreatic stellate cells in chronic pancreatitis: Focus on therapeutic drugs and natural compounds |
| title_sort | targeting pancreatic stellate cells in chronic pancreatitis focus on therapeutic drugs and natural compounds |
| topic | CP PSCs natural compounds pancreatic fibrosis anti-fibrotic drug |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1042651/full |
| work_keys_str_mv | AT yangwu targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT chunzhang targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT meiguo targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT weikanghu targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT yanglingqiu targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT mengranli targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT dongxu targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT pengfeiwu targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT jingsun targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT runshi targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT zilizhang targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds AT kuirongjiang targetingpancreaticstellatecellsinchronicpancreatitisfocusontherapeuticdrugsandnaturalcompounds |