Interleukin-1α Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation

Interleukin-1α Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation

Eosinophils contribute to allergic inflammation in asthma in part via elaboration of a complex milieu of soluble mediators. Human bronchial fibroblasts (HBF) respond to stimulation by these mediators by acquiring a pro-inflammatory profile including induction of interleukin 6 (IL6) and IL8. This stu...

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Bibliographic Details
Main Authors: Ksenija Bernau, Jonathan P. Leet, Heather Floerke, Ellen M. Bruhn, Andrea L. Noll, Ivy S. McDermott, Stephane Esnault, Nizar N. Jarjour, Nathan Sandbo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
eosinophil
fibroblast
asthma
IL6
IL8
IL1α
Online Access:https://www.mdpi.com/2073-4409/10/3/528

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