Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior
Introduction: Violent behavior is influenced by genetic factors, and the MAOA-uVNTR polymorphism has been associated with violent behavior, specifically the low activity variant. It has been suggested that this polymorphism impacts on grey matter concentration in structures associated with behaviora...
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Permanyer
2015-01-01
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| Series: | Revista Médica del Hospital General de México |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0185106315000049 |
| _version_ | 1818575177020080128 |
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| author | C. Romero-Rebollar F. Ostrosky-Shejet B. Camarena-Medellín M.A. Bobes-León K.X. Díaz-Galván M.L. Pérez-López |
| author_facet | C. Romero-Rebollar F. Ostrosky-Shejet B. Camarena-Medellín M.A. Bobes-León K.X. Díaz-Galván M.L. Pérez-López |
| author_sort | C. Romero-Rebollar |
| collection | DOAJ |
| description | Introduction: Violent behavior is influenced by genetic factors, and the MAOA-uVNTR polymorphism has been associated with violent behavior, specifically the low activity variant. It has been suggested that this polymorphism impacts on grey matter concentration in structures associated with behavioral inhibition and emotion processing, however in previous imaging studies well defined violent subjects have not been explored.
Objective: To investigate the effect of MAOA-uVNTR polymorphism on brain structure of violent subjects.
Methods: The grey matter concentration of 47 adult male subjects from a community sample classified as violent or controls, was assessed through DARTEL-voxel-based morphometry technique.
Results: A significant genotype by behavior interaction was found in which violent-low activity allele carriers had decrease of grey matter concentration in right superior temporal pole compared to controls of the same allelic variation.
Discussion: This findings suggests that grey matter integrity in superior temporal pole could be a neurobiological correlate of the allelic association between MAOA-uVNTR polymorphism and violent behavior due to its implication in socio-emotional processing. |
| first_indexed | 2024-12-15T00:36:48Z |
| format | Article |
| id | doaj.art-33b7bcdbe53341e0890a3c3c43445816 |
| institution | Directory Open Access Journal |
| issn | 0185-1063 |
| language | English |
| last_indexed | 2024-12-15T00:36:48Z |
| publishDate | 2015-01-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista Médica del Hospital General de México |
| spelling | doaj.art-33b7bcdbe53341e0890a3c3c434458162022-12-21T22:41:47ZengPermanyerRevista Médica del Hospital General de México0185-10632015-01-01781132010.1016/j.hgmx.2015.03.003Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behaviorC. Romero-Rebollar0F. Ostrosky-Shejet1B. Camarena-Medellín2M.A. Bobes-León3K.X. Díaz-Galván4M.L. Pérez-López5Laboratorio de Neuropsicología y Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México (UNAM), México, D. F., MexicoLaboratorio de Neuropsicología y Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México (UNAM), México, D. F., MexicoInstituto Nacional de Psiquiatría, Ramón de la Fuente Muñiz, México, D. F., MexicoDepartamento de Neurociencia Cognitiva, Centro de Neurociencias de Cuba (CNEURO), La Habana, CubaLaboratorio de Neuropsicología y Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México (UNAM), México, D. F., MexicoLaboratorio de Neuropsicología y Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México (UNAM), México, D. F., MexicoIntroduction: Violent behavior is influenced by genetic factors, and the MAOA-uVNTR polymorphism has been associated with violent behavior, specifically the low activity variant. It has been suggested that this polymorphism impacts on grey matter concentration in structures associated with behavioral inhibition and emotion processing, however in previous imaging studies well defined violent subjects have not been explored. Objective: To investigate the effect of MAOA-uVNTR polymorphism on brain structure of violent subjects. Methods: The grey matter concentration of 47 adult male subjects from a community sample classified as violent or controls, was assessed through DARTEL-voxel-based morphometry technique. Results: A significant genotype by behavior interaction was found in which violent-low activity allele carriers had decrease of grey matter concentration in right superior temporal pole compared to controls of the same allelic variation. Discussion: This findings suggests that grey matter integrity in superior temporal pole could be a neurobiological correlate of the allelic association between MAOA-uVNTR polymorphism and violent behavior due to its implication in socio-emotional processing.http://www.sciencedirect.com/science/article/pii/S0185106315000049Magnetic resonance imagingMonoamine oxidase AViolence |
| spellingShingle | C. Romero-Rebollar F. Ostrosky-Shejet B. Camarena-Medellín M.A. Bobes-León K.X. Díaz-Galván M.L. Pérez-López Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior Revista Médica del Hospital General de México Magnetic resonance imaging Monoamine oxidase A Violence |
| title | Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior |
| title_full | Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior |
| title_fullStr | Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior |
| title_full_unstemmed | Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior |
| title_short | Brain morphometric correlates of MAOA-uVNTR polymorphism in violent behavior |
| title_sort | brain morphometric correlates of maoa uvntr polymorphism in violent behavior |
| topic | Magnetic resonance imaging Monoamine oxidase A Violence |
| url | http://www.sciencedirect.com/science/article/pii/S0185106315000049 |
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