Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI
Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.737050/full |
| _version_ | 1818916136980316160 |
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| author | Daria Boscolo Daria Kostyleva Mohammad Javad Safari Vasiliki Anagnostatou Juha Äystö Juha Äystö Soumya Bagchi Tim Binder Georgios Dedes Peter Dendooven Timo Dickel Timo Dickel Vasyl Drozd Vasyl Drozd Bernhard Franczack Hans Geissel Hans Geissel Chiara Gianoli Christian Graeff Tuomas Grahn Tuomas Grahn Florian Greiner Emma Haettner Roghieh Haghani Muhsin N. Harakeh Felix Horst Christine Hornung Christine Hornung Jan-Paul Hucka Jan-Paul Hucka Nasser Kalantar-Nayestanaki Erika Kazantseva Birgit Kindler Ronja Knöbel Natalia Kuzminchuk-Feuerstein Bettina Lommel Ivan Mukha Chiara Nociforo Shunki Ishikawa Giulio Lovatti Munetaka Nitta Ikechi Ozoemelam Stephane Pietri Wolfgang R. Plaß Wolfgang R. Plaß Andrej Prochazka Sivaji Purushothaman Claire-Anne Reidel Heidi Roesch Heidi Roesch Fabio Schirru Christoph Schuy Olga Sokol Timo Steinsberger Timo Steinsberger Yoshiki K. Tanaka Isao Tanihata Isao Tanihata Isao Tanihata Peter Thirolf Walter Tinganelli Bernd Voss Uli Weber Helmut Weick John S. Winfield Martin Winkler Jianwei Zhao Jianwei Zhao Christoph Scheidenberger Christoph Scheidenberger Katia Parodi Marco Durante Marco Durante the Super-FRS Experiment Collaboration |
| author_facet | Daria Boscolo Daria Kostyleva Mohammad Javad Safari Vasiliki Anagnostatou Juha Äystö Juha Äystö Soumya Bagchi Tim Binder Georgios Dedes Peter Dendooven Timo Dickel Timo Dickel Vasyl Drozd Vasyl Drozd Bernhard Franczack Hans Geissel Hans Geissel Chiara Gianoli Christian Graeff Tuomas Grahn Tuomas Grahn Florian Greiner Emma Haettner Roghieh Haghani Muhsin N. Harakeh Felix Horst Christine Hornung Christine Hornung Jan-Paul Hucka Jan-Paul Hucka Nasser Kalantar-Nayestanaki Erika Kazantseva Birgit Kindler Ronja Knöbel Natalia Kuzminchuk-Feuerstein Bettina Lommel Ivan Mukha Chiara Nociforo Shunki Ishikawa Giulio Lovatti Munetaka Nitta Ikechi Ozoemelam Stephane Pietri Wolfgang R. Plaß Wolfgang R. Plaß Andrej Prochazka Sivaji Purushothaman Claire-Anne Reidel Heidi Roesch Heidi Roesch Fabio Schirru Christoph Schuy Olga Sokol Timo Steinsberger Timo Steinsberger Yoshiki K. Tanaka Isao Tanihata Isao Tanihata Isao Tanihata Peter Thirolf Walter Tinganelli Bernd Voss Uli Weber Helmut Weick John S. Winfield Martin Winkler Jianwei Zhao Jianwei Zhao Christoph Scheidenberger Christoph Scheidenberger Katia Parodi Marco Durante Marco Durante the Super-FRS Experiment Collaboration |
| author_sort | Daria Boscolo |
| collection | DOAJ |
| description | Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy. |
| first_indexed | 2024-12-20T00:13:23Z |
| format | Article |
| id | doaj.art-33b862ca45f24852bdc997b710c3a1aa |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T00:13:23Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-33b862ca45f24852bdc997b710c3a1aa2022-12-21T20:00:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.737050737050Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSIDaria Boscolo0Daria Kostyleva1Mohammad Javad Safari2Vasiliki Anagnostatou3Juha Äystö4Juha Äystö5Soumya Bagchi6Tim Binder7Georgios Dedes8Peter Dendooven9Timo Dickel10Timo Dickel11Vasyl Drozd12Vasyl Drozd13Bernhard Franczack14Hans Geissel15Hans Geissel16Chiara Gianoli17Christian Graeff18Tuomas Grahn19Tuomas Grahn20Florian Greiner21Emma Haettner22Roghieh Haghani23Muhsin N. Harakeh24Felix Horst25Christine Hornung26Christine Hornung27Jan-Paul Hucka28Jan-Paul Hucka29Nasser Kalantar-Nayestanaki30Erika Kazantseva31Birgit Kindler32Ronja Knöbel33Natalia Kuzminchuk-Feuerstein34Bettina Lommel35Ivan Mukha36Chiara Nociforo37Shunki Ishikawa38Giulio Lovatti39Munetaka Nitta40Ikechi Ozoemelam41Stephane Pietri42Wolfgang R. Plaß43Wolfgang R. Plaß44Andrej Prochazka45Sivaji Purushothaman46Claire-Anne Reidel47Heidi Roesch48Heidi Roesch49Fabio Schirru50Christoph Schuy51Olga Sokol52Timo Steinsberger53Timo Steinsberger54Yoshiki K. Tanaka55Isao Tanihata56Isao Tanihata57Isao Tanihata58Peter Thirolf59Walter Tinganelli60Bernd Voss61Uli Weber62Helmut Weick63John S. Winfield64Martin Winkler65Jianwei Zhao66Jianwei Zhao67Christoph Scheidenberger68Christoph Scheidenberger69Katia Parodi70Marco Durante71Marco Durante72the Super-FRS Experiment CollaborationGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyLudwig-Maximilians-Universität München, Munich, GermanyLudwig-Maximilians-Universität München, Munich, GermanyUniversity of Jyväskylä, Jyväskylä, FinlandHelsinki Institute of Physics, Helsinki, FinlandIndian Institute of Technology, Dhanbad, IndiaLudwig-Maximilians-Universität München, Munich, GermanyLudwig-Maximilians-Universität München, Munich, GermanyUniversity Medical Center Groningen, Groningen, NetherlandsGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyJustus-Liebig-Universität Gießen, Gießen, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyUniversity of Groningen, Groningen, NetherlandsGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyJustus-Liebig-Universität Gießen, Gießen, GermanyLudwig-Maximilians-Universität München, Munich, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyUniversity of Jyväskylä, Jyväskylä, FinlandHelsinki Institute of Physics, Helsinki, FinlandGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyLudwig-Maximilians-Universität München, Munich, GermanyUniversity of Groningen, Groningen, NetherlandsGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyTechnische Universität Darmstadt, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyTechnische Universität Darmstadt, Darmstadt, GermanyUniversity of Groningen, Groningen, NetherlandsGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany0Tohoku University, Sendai, JapanLudwig-Maximilians-Universität München, Munich, GermanyLudwig-Maximilians-Universität München, Munich, Germany1Fontys University of Applied Sciences, Eindhoven, NetherlandsGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyJustus-Liebig-Universität Gießen, Gießen, Germany2MedAustron, Wiener Neustadt, AustriaGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyTechnische Universität Darmstadt, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyTechnische Universität Darmstadt, Darmstadt, Germany3RIKEN High Energy Nuclear Physics Laboratory, Wako, Japan4Research Center for Nuclear Physics, Osaka University, Osaka, Japan5Peking University, Beijing, China6Institute of Modern Physics, Lanzhou, ChinaLudwig-Maximilians-Universität München, Munich, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany5Peking University, Beijing, ChinaGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyJustus-Liebig-Universität Gießen, Gießen, GermanyLudwig-Maximilians-Universität München, Munich, GermanyGSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, GermanyTechnische Universität Darmstadt, Darmstadt, GermanySeveral techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.https://www.frontiersin.org/articles/10.3389/fonc.2021.737050/fullparticle therapyradioactive ion beamscarbon ionsoxygen ionsPET |
| spellingShingle | Daria Boscolo Daria Kostyleva Mohammad Javad Safari Vasiliki Anagnostatou Juha Äystö Juha Äystö Soumya Bagchi Tim Binder Georgios Dedes Peter Dendooven Timo Dickel Timo Dickel Vasyl Drozd Vasyl Drozd Bernhard Franczack Hans Geissel Hans Geissel Chiara Gianoli Christian Graeff Tuomas Grahn Tuomas Grahn Florian Greiner Emma Haettner Roghieh Haghani Muhsin N. Harakeh Felix Horst Christine Hornung Christine Hornung Jan-Paul Hucka Jan-Paul Hucka Nasser Kalantar-Nayestanaki Erika Kazantseva Birgit Kindler Ronja Knöbel Natalia Kuzminchuk-Feuerstein Bettina Lommel Ivan Mukha Chiara Nociforo Shunki Ishikawa Giulio Lovatti Munetaka Nitta Ikechi Ozoemelam Stephane Pietri Wolfgang R. Plaß Wolfgang R. Plaß Andrej Prochazka Sivaji Purushothaman Claire-Anne Reidel Heidi Roesch Heidi Roesch Fabio Schirru Christoph Schuy Olga Sokol Timo Steinsberger Timo Steinsberger Yoshiki K. Tanaka Isao Tanihata Isao Tanihata Isao Tanihata Peter Thirolf Walter Tinganelli Bernd Voss Uli Weber Helmut Weick John S. Winfield Martin Winkler Jianwei Zhao Jianwei Zhao Christoph Scheidenberger Christoph Scheidenberger Katia Parodi Marco Durante Marco Durante the Super-FRS Experiment Collaboration Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI Frontiers in Oncology particle therapy radioactive ion beams carbon ions oxygen ions PET |
| title | Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI |
| title_full | Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI |
| title_fullStr | Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI |
| title_full_unstemmed | Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI |
| title_short | Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI |
| title_sort | radioactive beams for image guided particle therapy the barb experiment at gsi |
| topic | particle therapy radioactive ion beams carbon ions oxygen ions PET |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.737050/full |
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