SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders
The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/7/1052 |
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| author | Marco Benazzo Irene Cassaniti Eugenia Maiorano Anna Calastri Federica Novazzi Alice Bonetti Antonella Sarasini Raffaele Bruno Fausto Baldanti |
| author_facet | Marco Benazzo Irene Cassaniti Eugenia Maiorano Anna Calastri Federica Novazzi Alice Bonetti Antonella Sarasini Raffaele Bruno Fausto Baldanti |
| author_sort | Marco Benazzo |
| collection | DOAJ |
| description | The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays for the characterization of SARS-CoV-2 IgG and SARS-CoV-2 RNA, respectively, were performed at the time of enrolment and after 7 and 14 days. Patients were stratified according to the symptoms’ onset. A total of 52 patients (75.4%) were diagnosed as COVID-19 positive being SARS-CoV-2 RNA and/or SARS-CoV-2 IgG positive. The remaining 17 (24.6%) were negative for COVID-19 and excluded from the analysis. We reported that only 34 out of 52 patients (65.4%) were positive for SARS-CoV-2 RNA. Moreover, the median time from onset of symptoms and enrolment was significantly higher in those patients with negative SARS-CoV-2 RNA in nasal swabs, suggesting that symptoms might last longer than SARS-CoV-2 replication. The great majority of patients (80%) developed SARS-CoV-2 IgG at three weeks after symptoms’ onset while the detectability of SARS-CoV-2 RNA dramatically decreased over time, suggesting the crucial role of combination of molecular and serological assays for the diagnosis of COVID-19 in those patients reporting mild symptoms. |
| first_indexed | 2024-03-10T18:27:27Z |
| format | Article |
| id | doaj.art-33b8e2cc9a694f7da224a97e83d997ec |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T18:27:27Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-33b8e2cc9a694f7da224a97e83d997ec2023-11-20T06:53:29ZengMDPI AGMicroorganisms2076-26072020-07-0187105210.3390/microorganisms8071052SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste DisordersMarco Benazzo0Irene Cassaniti1Eugenia Maiorano2Anna Calastri3Federica Novazzi4Alice Bonetti5Antonella Sarasini6Raffaele Bruno7Fausto Baldanti8Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyMolecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyDepartment of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyDepartment of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyMolecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyMolecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyMolecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, ItalyDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, ItalyThe main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. A cohort of 69 patients with olfactory and taste disorders (OTDs) were enrolled and prospectively monitored. Serological and molecular assays for the characterization of SARS-CoV-2 IgG and SARS-CoV-2 RNA, respectively, were performed at the time of enrolment and after 7 and 14 days. Patients were stratified according to the symptoms’ onset. A total of 52 patients (75.4%) were diagnosed as COVID-19 positive being SARS-CoV-2 RNA and/or SARS-CoV-2 IgG positive. The remaining 17 (24.6%) were negative for COVID-19 and excluded from the analysis. We reported that only 34 out of 52 patients (65.4%) were positive for SARS-CoV-2 RNA. Moreover, the median time from onset of symptoms and enrolment was significantly higher in those patients with negative SARS-CoV-2 RNA in nasal swabs, suggesting that symptoms might last longer than SARS-CoV-2 replication. The great majority of patients (80%) developed SARS-CoV-2 IgG at three weeks after symptoms’ onset while the detectability of SARS-CoV-2 RNA dramatically decreased over time, suggesting the crucial role of combination of molecular and serological assays for the diagnosis of COVID-19 in those patients reporting mild symptoms.https://www.mdpi.com/2076-2607/8/7/1052anosmiaageusiaSARS-CoV-2serology |
| spellingShingle | Marco Benazzo Irene Cassaniti Eugenia Maiorano Anna Calastri Federica Novazzi Alice Bonetti Antonella Sarasini Raffaele Bruno Fausto Baldanti SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders Microorganisms anosmia ageusia SARS-CoV-2 serology |
| title | SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders |
| title_full | SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders |
| title_fullStr | SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders |
| title_full_unstemmed | SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders |
| title_short | SARS-CoV-2 Virologic and Immunologic Correlates in Patients with Olfactory and Taste Disorders |
| title_sort | sars cov 2 virologic and immunologic correlates in patients with olfactory and taste disorders |
| topic | anosmia ageusia SARS-CoV-2 serology |
| url | https://www.mdpi.com/2076-2607/8/7/1052 |
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