Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor. It expresses high levels of heat shock protein (HSP60), which is associated with poor prognosis. Chemodynamic therapy (CDT) can be improved by photothermal therapy (PTT) and facilitate tumor eradication. Therefore, it is nece...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522009881 |
| _version_ | 1811183850661871616 |
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| author | Qinglong Guo Mengyuan Yin Junjuan Fan Yafei Yang Tao Liu Haisheng Qian Xingliang Dai Xianwen Wang |
| author_facet | Qinglong Guo Mengyuan Yin Junjuan Fan Yafei Yang Tao Liu Haisheng Qian Xingliang Dai Xianwen Wang |
| author_sort | Qinglong Guo |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor. It expresses high levels of heat shock protein (HSP60), which is associated with poor prognosis. Chemodynamic therapy (CDT) can be improved by photothermal therapy (PTT) and facilitate tumor eradication. Therefore, it is necessary to develop novel agents that synergize with the tumor killing effects of PTT/CDT by downregulating HSP60. Based on The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases and clinical cases, this study determined that HSP60 was upregulated and associated with reduced overall survival (OS) in GBM patients. Herein, TA-VOx nanobranches (TA-VOx NBs) were successfully synthesized by a one-step self-assembly procedure, which had excellent photothermal conversion characteristics and improved peroxidase-mimicking activity at elevated temperatures. Moreover, TA-VOx NBs can degrade to VO2+ in a slightly acidic tumor microenvironment. In vitro and in vivo studies showed that TA-VOx NBs synergized with PTT/CDT and improved glioma eradication under 808 nm irradiation due to the heat-induced ROS generation and the inhibition of HSP60. Furthermore, TA-VOx NBs were rapidly cleared by the kidney and showed good biosafety. Combined with the ease of fabrication, this is a promising nanomaterial that can be introduced for clinical translation in cancer therapy. |
| first_indexed | 2024-04-11T13:04:48Z |
| format | Article |
| id | doaj.art-33b999ba393a4e2885c83b5049437074 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-11T13:04:48Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-33b999ba393a4e2885c83b50494370742022-12-22T04:22:50ZengElsevierMaterials & Design0264-12752022-12-01224111366Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60Qinglong Guo0Mengyuan Yin1Junjuan Fan2Yafei Yang3Tao Liu4Haisheng Qian5Xingliang Dai6Xianwen Wang7Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, PR China; School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, PR ChinaDepartment of Pharmacy, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215000, PR ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, PR ChinaSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR ChinaSchool of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, PR China; Corresponding authors.School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, PR China; Corresponding authors.Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor. It expresses high levels of heat shock protein (HSP60), which is associated with poor prognosis. Chemodynamic therapy (CDT) can be improved by photothermal therapy (PTT) and facilitate tumor eradication. Therefore, it is necessary to develop novel agents that synergize with the tumor killing effects of PTT/CDT by downregulating HSP60. Based on The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases and clinical cases, this study determined that HSP60 was upregulated and associated with reduced overall survival (OS) in GBM patients. Herein, TA-VOx nanobranches (TA-VOx NBs) were successfully synthesized by a one-step self-assembly procedure, which had excellent photothermal conversion characteristics and improved peroxidase-mimicking activity at elevated temperatures. Moreover, TA-VOx NBs can degrade to VO2+ in a slightly acidic tumor microenvironment. In vitro and in vivo studies showed that TA-VOx NBs synergized with PTT/CDT and improved glioma eradication under 808 nm irradiation due to the heat-induced ROS generation and the inhibition of HSP60. Furthermore, TA-VOx NBs were rapidly cleared by the kidney and showed good biosafety. Combined with the ease of fabrication, this is a promising nanomaterial that can be introduced for clinical translation in cancer therapy.http://www.sciencedirect.com/science/article/pii/S0264127522009881GlioblastomaPhotothermal therapyChemodynamic therapyPeroxidase-mimickingHSP60 |
| spellingShingle | Qinglong Guo Mengyuan Yin Junjuan Fan Yafei Yang Tao Liu Haisheng Qian Xingliang Dai Xianwen Wang Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60 Materials & Design Glioblastoma Photothermal therapy Chemodynamic therapy Peroxidase-mimicking HSP60 |
| title | Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60 |
| title_full | Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60 |
| title_fullStr | Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60 |
| title_full_unstemmed | Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60 |
| title_short | Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60 |
| title_sort | peroxidase mimicking ta vox nanobranches for enhanced photothermal chemodynamic therapy of glioma by inhibiting the expression of hsp60 |
| topic | Glioblastoma Photothermal therapy Chemodynamic therapy Peroxidase-mimicking HSP60 |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522009881 |
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