Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex

Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex

Clinical studies have demonstrated that exposure to the inhalational general anesthetic nitrous oxide (N2O) produces antidepressant effects in depressed patients. However, the mechanisms underlying the antidepressant effects of N2O remain largely unknown. Neuronal nitric oxide synthase (nNOS)–mediat...

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Bibliographic Details
Main Authors: Wei Liu, Qian Li, Binglu Ye, Hang Cao, Fuyi Shen, Zhendong Xu, Weijia Du, Fei Guo, Jinqi Liu, Tianyu Li, Bing Zhang, Zhiqiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Psychiatry
Subjects:
nitrous oxide (N2O)
depression
mPFC
burst firing
neuronal nitric oxide synthase (nNOS)
BDNF
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00837/full

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