Single cell RNA-sequencing analysis reveals that N-acetylcysteine partially reverses hepatic immune dysfunction in biliary atresia

Single cell RNA-sequencing analysis reveals that N-acetylcysteine partially reverses hepatic immune dysfunction in biliary atresia

Background & Aims: Our previous study indicated that CD177+ neutrophil activation has a vital role in the pathogenesis of biliary atresia (BA), which is partially ameliorated by N-acetylcysteine (NAC) treatment. Here, we evaluated the clinical efficacy of NAC treatment and profiled liver-res...

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Bibliographic Details
Main Authors: Rongchen Ye, Sige Ma, Yan Chen, Jiarou Shan, Ledong Tan, Liang Su, Yanlu Tong, Ziyang Zhao, Hongjiao Chen, Ming Fu, Zhipeng Guo, Xiaoyu Zuo, Jiakang Yu, Wei Zhong, Jixiao Zeng, Fei Liu, Chenwei Chai, Xisi Guan, Zhe Wang, Tao Liu, Jiankun Liang, Yan Zhang, Hongguang Shi, Zhe Wen, Huimin Xia, Ruizhong Zhang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:JHEP Reports
Subjects:
scRNA-seq
Biliary atresia
N-acetylcysteine
Innate immune response
Neutrophil
Oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923002392

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