Excessive intake of sugar: An accomplice of inflammation
High sugar intake has long been recognized as a potential environmental risk factor for increased incidence of many non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes (T2D). Dietary sugars are mainly hexoses, including glucose, fructose, suc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.988481/full |
| _version_ | 1817998723710451712 |
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| author | Xiao Ma Fang Nan Hantian Liang Panyin Shu Xinzou Fan Xiaoshuang Song Yanfeng Hou Dunfang Zhang |
| author_facet | Xiao Ma Fang Nan Hantian Liang Panyin Shu Xinzou Fan Xiaoshuang Song Yanfeng Hou Dunfang Zhang |
| author_sort | Xiao Ma |
| collection | DOAJ |
| description | High sugar intake has long been recognized as a potential environmental risk factor for increased incidence of many non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes (T2D). Dietary sugars are mainly hexoses, including glucose, fructose, sucrose and High Fructose Corn Syrup (HFCS). These sugars are primarily absorbed in the gut as fructose and glucose. The consumption of high sugar beverages and processed foods has increased significantly over the past 30 years. Here, we summarize the effects of consuming high levels of dietary hexose on rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, inflammatory bowel disease (IBD) and low-grade chronic inflammation. Based on these reported findings, we emphasize that dietary sugars and mixed processed foods may be a key factor leading to the occurrence and aggravation of inflammation. We concluded that by revealing the roles that excessive intake of hexose has on the regulation of human inflammatory diseases are fundamental questions that need to be solved urgently. Moreover, close attention should also be paid to the combination of high glucose-mediated immune imbalance and tumor development, and strive to make substantial contributions to reverse tumor immune escape. |
| first_indexed | 2024-04-14T02:57:44Z |
| format | Article |
| id | doaj.art-33bfed9c70c4445faf3e5f9953a3cc17 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T02:57:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-33bfed9c70c4445faf3e5f9953a3cc172022-12-22T02:16:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.988481988481Excessive intake of sugar: An accomplice of inflammationXiao Ma0Fang Nan1Hantian Liang2Panyin Shu3Xinzou Fan4Xiaoshuang Song5Yanfeng Hou6Dunfang Zhang7Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Rheumatology and Autoimmunology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational medicine, Shandong medicine and Health Key Laboratory of Rheumatism, Jinan, ChinaDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaHigh sugar intake has long been recognized as a potential environmental risk factor for increased incidence of many non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes (T2D). Dietary sugars are mainly hexoses, including glucose, fructose, sucrose and High Fructose Corn Syrup (HFCS). These sugars are primarily absorbed in the gut as fructose and glucose. The consumption of high sugar beverages and processed foods has increased significantly over the past 30 years. Here, we summarize the effects of consuming high levels of dietary hexose on rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, inflammatory bowel disease (IBD) and low-grade chronic inflammation. Based on these reported findings, we emphasize that dietary sugars and mixed processed foods may be a key factor leading to the occurrence and aggravation of inflammation. We concluded that by revealing the roles that excessive intake of hexose has on the regulation of human inflammatory diseases are fundamental questions that need to be solved urgently. Moreover, close attention should also be paid to the combination of high glucose-mediated immune imbalance and tumor development, and strive to make substantial contributions to reverse tumor immune escape.https://www.frontiersin.org/articles/10.3389/fimmu.2022.988481/fullmacrophagesautoimmune disordersTh17 cells (Th17)low-grade chronic inflammationTGF-betaIL-1beta |
| spellingShingle | Xiao Ma Fang Nan Hantian Liang Panyin Shu Xinzou Fan Xiaoshuang Song Yanfeng Hou Dunfang Zhang Excessive intake of sugar: An accomplice of inflammation Frontiers in Immunology macrophages autoimmune disorders Th17 cells (Th17) low-grade chronic inflammation TGF-beta IL-1beta |
| title | Excessive intake of sugar: An accomplice of inflammation |
| title_full | Excessive intake of sugar: An accomplice of inflammation |
| title_fullStr | Excessive intake of sugar: An accomplice of inflammation |
| title_full_unstemmed | Excessive intake of sugar: An accomplice of inflammation |
| title_short | Excessive intake of sugar: An accomplice of inflammation |
| title_sort | excessive intake of sugar an accomplice of inflammation |
| topic | macrophages autoimmune disorders Th17 cells (Th17) low-grade chronic inflammation TGF-beta IL-1beta |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.988481/full |
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