Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points
Synaptic integrity and function depend on myriad proteins - labile molecules with finite lifetimes that need to be continually replaced with freshly synthesized copies. Here we describe experiments designed to expose synaptic (and neuronal) properties and functions that are particularly sensitive to...
Main Authors: | Laurie D. Cohen, Tamar Ziv, Noam E. Ziv |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-12-01
|
Series: | Frontiers in Molecular Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1038614/full |
Similar Items
-
Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses
by: Christoph T Schanzenbächer, et al.
Published: (2018-02-01) -
APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
by: Tomas Fanutza, et al.
Published: (2015-11-01) -
Two hit mitochondrial-driven model of synapse loss in neurodegeneration
by: Sergei V. Baranov, et al.
Published: (2021-10-01) -
Temperature-dependent structural plasticity of hippocampal synapses
by: Zhendong Feng, et al.
Published: (2022-10-01) -
The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
by: Chuan Tang, et al.
Published: (2022-12-01)